EIF4E [The Human Chemical-Genetic Interaction Map Project]

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======= EIF4E =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF4E
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 4E
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1977|1977]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06730|P06730]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF4E&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF4E|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/133440|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. {ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IF4E|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eukaryotic initiation factor 4G binding|
|regulation of translation at postsynapse, modulating synaptic transmission|
|regulation of translation at postsynapse|
|regulation of translation at synapse|
|regulation of translation at synapse, modulating synaptic transmission|
|RNA cap binding|
|mRNA cap binding complex|
|RNA 7-methylguanosine cap binding|
|eukaryotic translation initiation factor 4F complex|
|chromatoid body|
|RISC complex|
|postsynaptic modulation of chemical synaptic transmission|
|postsynaptic cytosol|
|cellular response to dexamethasone stimulus|
|behavioral fear response|
|behavioral defense response|
|fear response|
|repressing transcription factor binding|
|response to dexamethasone|
|translation initiation factor activity|
|cellular response to glucocorticoid stimulus|
|cellular response to corticosteroid stimulus|
|cytoplasmic stress granule|
|multicellular organismal response to stress|
|cytoplasmic ribonucleoprotein granule|
|negative regulation of autophagy|
|P-body|
|cellular response to ketone|
|response to antineoplastic agent|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|negative regulation of translation|
|stem cell population maintenance|
|maintenance of cell number|
|translational initiation|
|response to glucocorticoid|
|negative regulation of cellular amide metabolic process|
|protein export from nucleus|
|positive regulation of mitotic cell cycle|
|mRNA transport|
|nuclear export|
|response to corticosteroid|
|lung development|
|respiratory tube development|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|RNA transport|
|nucleic acid transport|
|response to ketone|
|establishment of RNA localization|
|respiratory system development|
|RNA localization|
|negative regulation of neuron differentiation|
|nucleobase-containing compound transport|
|negative regulation of cellular catabolic process|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|negative regulation of neurogenesis|
|response to xenobiotic stimulus|
|negative regulation of catabolic process|
|negative regulation of nervous system development|
|response to steroid hormone|
|regulation of autophagy|
|negative regulation of cell development|
|enzyme binding|
|glutamatergic synapse|
|regulation of translation|
|positive regulation of cell cycle|
|translation|
|regulation of cellular amide metabolic process|
|cellular response to drug|
|peptide biosynthetic process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|cellular response to lipid|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cellular response to organic cyclic compound|
|behavior|
|mitotic cell cycle process|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|regulation of neuron differentiation|
|mitotic cell cycle|
|perinuclear region of cytoplasm|
|viral process|
|negative regulation of cell differentiation|
|symbiotic process|
|cellular amide metabolic process|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|tube development|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|intracellular protein transport|
|regulation of catabolic process|
|cell cycle process|
|response to drug|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|negative regulation of protein metabolic process|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|cell cycle|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|generation of neurons|
|peptide transport|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.23|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.14|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.85|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.79|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.79|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.74|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.71|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.78|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.78|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.79|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.82|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.08|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.24|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.31|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.61|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rptor|RPTOR]]|0.679|
|[[:human genes:h:hars|HARS]]|0.659|
|[[:human genes:r:rnmt|RNMT]]|0.611|
|[[:human genes:r:rtcb|RTCB]]|0.601|
|[[:human genes:m:meaf6|MEAF6]]|0.598|
|[[:human genes:a:aars|AARS]]|0.582|
|[[:human genes:g:gfpt1|GFPT1]]|0.574|
|[[:human genes:h:hspd1|HSPD1]]|0.57|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.566|
|[[:human genes:n:nars|NARS]]|0.566|
|[[:human genes:p:pelo|PELO]]|0.565|
|[[:human genes:g:gmppb|GMPPB]]|0.563|
|[[:human genes:u:uap1|UAP1]]|0.56|
|[[:human genes:m:mtor|MTOR]]|0.559|
|[[:human genes:d:dpagt1|DPAGT1]]|0.552|
|[[:human genes:c:ccdc101|CCDC101]]|0.55|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.542|
|[[:human genes:t:thg1l|THG1L]]|0.537|
|[[:human genes:w:wdr24|WDR24]]|0.536|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.522|
|[[:human genes:d:dhps|DHPS]]|0.52|
|[[:human genes:n:nae1|NAE1]]|0.512|
|[[:human genes:v:vrk1|VRK1]]|0.509|
|[[:human genes:o:otud5|OTUD5]]|0.509|
|[[:human genes:p:polr3b|POLR3B]]|0.507|
|[[:human genes:t:tti2|TTI2]]|0.506|
|[[:human genes:t:tmem41b|TMEM41B]]|0.503|
|[[:human genes:g:gnb1l|GNB1L]]|0.501|
|[[:human genes:p:pmm2|PMM2]]|0.499|
|[[:human genes:c:cct7|CCT7]]|0.497|
|[[:human genes:s:srp68|SRP68]]|0.497|
|[[:human genes:a:alg1|ALG1]]|0.497|
|[[:human genes:a:adsl|ADSL]]|0.496|
|[[:human genes:e:eny2|ENY2]]|0.495|
|[[:human genes:c:csnk2b|CSNK2B]]|0.494|
|[[:human genes:d:dhdds|DHDDS]]|0.494|
|[[:human genes:w:wdr59|WDR59]]|0.488|
|[[:human genes:p:polr3h|POLR3H]]|0.485|
|[[:human genes:g:gtf3a|GTF3A]]|0.484|
|[[:human genes:m:med23|MED23]]|0.482|
|[[:human genes:t:tsen34|TSEN34]]|0.481|
|[[:human genes:u:uxt|UXT]]|0.48|
|[[:human genes:y:yars|YARS]]|0.48|
|[[:human genes:t:tgs1|TGS1]]|0.478|
|[[:human genes:m:med16|MED16]]|0.477|
|[[:human genes:l:lsmd1|LSMD1]]|0.475|
|[[:human genes:d:dohh|DOHH]]|0.475|
|[[:human genes:a:alg5|ALG5]]|0.474|
|[[:human genes:p:pam16|PAM16]]|0.474|
|[[:human genes:f:faf2|FAF2]]|0.474|
|[[:human genes:s:srp14|SRP14]]|0.474|
|[[:human genes:a:alg2|ALG2]]|0.473|
|[[:human genes:t:triap1|TRIAP1]]|0.467|
|[[:human genes:u:uhrf1|UHRF1]]|0.467|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.46|
|[[:human genes:s:spcs2|SPCS2]]|0.46|
|[[:human genes:u:utp23|UTP23]]|0.459|
|[[:human genes:o:osgep|OSGEP]]|0.459|
|[[:human genes:z:znf259|ZNF259]]|0.458|
|[[:human genes:m:mars|MARS]]|0.458|
|[[:human genes:s:seh1l|SEH1L]]|0.457|
|[[:human genes:h:hmgb2|HMGB2]]|0.457|
|[[:human genes:s:slc35b1|SLC35B1]]|0.457|
|[[:human genes:e:eprs|EPRS]]|0.456|
|[[:human genes:o:oraov1|ORAOV1]]|0.455|
|[[:human genes:m:mios|MIOS]]|0.455|
|[[:human genes:t:trmt5|TRMT5]]|0.455|
|[[:human genes:e:eif3f|EIF3F]]|0.454|
|[[:human genes:m:mllt1|MLLT1]]|0.454|
|[[:human genes:m:med4|MED4]]|0.452|
|[[:human genes:a:abcf1|ABCF1]]|0.452|
|[[:human genes:d:dad1|DAD1]]|0.45|
|[[:human genes:e:eif4g1|EIF4G1]]|0.448|
|[[:human genes:a:alg14|ALG14]]|0.448|
|[[:human genes:t:tle4|TLE4]]|0.448|
|[[:human genes:s:spcs3|SPCS3]]|0.446|
|[[:human genes:c:crcp|CRCP]]|0.444|
|[[:human genes:a:alg13|ALG13]]|0.443|
|[[:human genes:c:cbfb|CBFB]]|0.442|
|[[:human genes:z:znf608|ZNF608]]|0.442|
|[[:human genes:t:tsen54|TSEN54]]|0.441|
|[[:human genes:t:tsen2|TSEN2]]|0.441|
|[[:human genes:d:dpf2|DPF2]]|0.441|
|[[:human genes:t:tti1|TTI1]]|0.44|
|[[:human genes:s:sec61g|SEC61G]]|0.439|
|[[:human genes:m:mapk14|MAPK14]]|0.438|
|[[:human genes:s:srp72|SRP72]]|0.436|
|[[:human genes:p:pik3r4|PIK3R4]]|0.434|
|[[:human genes:m:max|MAX]]|0.433|
|[[:human genes:t:trnt1|TRNT1]]|0.431|
|[[:human genes:u:ube2g2|UBE2G2]]|0.43|
|[[:human genes:t:tmed10|TMED10]]|0.429|
|[[:human genes:r:rpe|RPE]]|0.428|
|[[:human genes:t:tbcd|TBCD]]|0.428|
|[[:human genes:t:timm13|TIMM13]]|0.427|
|[[:human genes:r:rpn1|RPN1]]|0.425|
|[[:human genes:w:wars|WARS]]|0.423|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.422|
|[[:human genes:d:ddost|DDOST]]|0.421|
|[[:human genes:d:derl2|DERL2]]|0.418|
|[[:human genes:t:taz|TAZ]]|0.416|
|[[:human genes:s:srp19|SRP19]]|0.416|
|[[:human genes:c:cars|CARS]]|0.415|
|[[:human genes:t:tbca|TBCA]]|0.414|
|[[:human genes:d:ddx20|DDX20]]|0.414|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.413|
|[[:human genes:r:rpp21|RPP21]]|0.412|
|[[:human genes:e:eno1|ENO1]]|0.411|
|[[:human genes:n:nsmce1|NSMCE1]]|0.411|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.41|
|[[:human genes:r:rad1|RAD1]]|0.41|
|[[:human genes:e:exoc4|EXOC4]]|0.41|
|[[:human genes:a:atp5j|ATP5J]]|0.409|
|[[:human genes:c:cmtr1|CMTR1]]|0.409|
|[[:human genes:a:apaf1|APAF1]]|0.409|
|[[:human genes:z:zzz3|ZZZ3]]|0.408|
|[[:human genes:d:dr1|DR1]]|0.408|
|[[:human genes:d:ddx55|DDX55]]|0.408|
|[[:human genes:a:atxn10|ATXN10]]|0.405|
|[[:human genes:p:plaa|PLAA]]|0.405|
|[[:human genes:b:btaf1|BTAF1]]|0.403|
|[[:human genes:t:tbp|TBP]]|0.401|
|[[:human genes:m:mad2l1|MAD2L1]]|0.4|
|[[:human genes:r:rbm14|RBM14]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 422/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|18/28|
|blood|18/28|
|bone|17/26|
|breast|14/33|
|central nervous system|33/56|
|cervix|3/4|
|colorectal|10/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|8/16|
|kidney|11/21|
|liver|9/20|
|lung|45/75|
|lymphocyte|9/16|
|ovary|19/26|
|pancreas|14/24|
|peripheral nervous system|11/16|
|plasma cell|7/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|14/22|
|urinary tract|14/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2389
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF4E Expression in NALM6 Cells: 7.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>