EIF5B [The Human Chemical-Genetic Interaction Map Project]

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======= EIF5B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF5B
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 5B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9669|9669]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60841|O60841]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF5B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF5B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606086|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes. {ECO:0000250|UniProtKB:P39730}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GTP EFTU|
|GTP EFTU D2|
|IF-2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation initiation factor activity|
|regulation of translational initiation|
|translational initiation|
|GTPase activity|
|regulation of translation|
|translation|
|GTP binding|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-2.87|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.6|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.44|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.44|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.38|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.32|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.12|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.09|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.94|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.79|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.7|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.71|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.81|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.89|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.9|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.95|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.99|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.02|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.03|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|2.05|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.1|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.14|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|2.14|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|2.21|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.35|
|[[:results:exp149|SB203580 25μM R03 exp149]]|2.37|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.57|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|2.6|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.529|
|[[:human genes:l:lrrc42|LRRC42]]|0.421|
|[[:human genes:n:naa11|NAA11]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 851
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF5B Expression in NALM6 Cells: 8.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>