ELANE [The Human Chemical-Genetic Interaction Map Project]

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======= ELANE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ELANE
  * **<color #00a2e8>Official Name</color>**: elastase, neutrophil expressed
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1991|1991]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08246|P08246]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ELANE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ELANE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/130130|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. {ECO:0000269|PubMed:15140022}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1986|
|Trypsin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|antibacterial peptide biosynthetic process|
|antimicrobial peptide biosynthetic process|
|neutrophil mediated killing of fungus|
|biosynthetic process of antibacterial peptides active against Gram-negative bacteria|
|antimicrobial peptide production|
|antibacterial peptide production|
|negative regulation of chemokine biosynthetic process|
|neutrophil mediated killing of gram-negative bacterium|
|negative regulation of interleukin-8 biosynthetic process|
|response to yeast|
|positive regulation of leukocyte tethering or rolling|
|neutrophil mediated killing of symbiont cell|
|neutrophil mediated killing of bacterium|
|neutrophil mediated cytotoxicity|
|acute inflammatory response to antigenic stimulus|
|regulation of leukocyte tethering or rolling|
|killing by host of symbiont cells|
|disruption by host of symbiont cells|
|killing of cells in other organism involved in symbiotic interaction|
|positive regulation of interleukin-8 biosynthetic process|
|disruption of cells of other organism involved in symbiotic interaction|
|positive regulation of leukocyte adhesion to vascular endothelial cell|
|leukocyte migration involved in inflammatory response|
|regulation of chemokine biosynthetic process|
|regulation of interleukin-8 biosynthetic process|
|positive regulation of cellular extravasation|
|negative regulation of interleukin-8 production|
|regulation of leukocyte adhesion to vascular endothelial cell|
|negative regulation of chemokine production|
|inflammatory response to antigenic stimulus|
|regulation of cellular extravasation|
|negative regulation of cytokine biosynthetic process|
|defense response to fungus|
|antibacterial humoral response|
|cytokine binding|
|leukocyte mediated cytotoxicity|
|response to fungus|
|positive regulation of interleukin-8 production|
|disruption of cells of other organism|
|killing of cells of other organism|
|transcriptional repressor complex|
|negative regulation of chemotaxis|
|phagocytic vesicle|
|specific granule lumen|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|extracellular matrix disassembly|
|positive regulation of cytokine biosynthetic process|
|regulation of interleukin-8 production|
|acute inflammatory response|
|modification by host of symbiont morphology or physiology|
|endopeptidase activity|
|interaction with symbiont|
|regulation of chemokine production|
|peptidase activity|
|defense response to Gram-negative bacterium|
|positive regulation of smooth muscle cell proliferation|
|secretory granule|
|cell killing|
|azurophil granule lumen|
|protease binding|
|regulation of cytokine biosynthetic process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|antimicrobial humoral response|
|positive regulation of leukocyte migration|
|regulation of smooth muscle cell proliferation|
|negative regulation of inflammatory response|
|response to UV|
|modification of morphology or physiology of other organism|
|serine-type endopeptidase activity|
|heparin binding|
|production of molecular mediator of immune response|
|regulation of leukocyte migration|
|negative regulation of defense response|
|regulation of chemotaxis|
|positive regulation of leukocyte cell-cell adhesion|
|transcription corepressor activity|
|positive regulation of cell-cell adhesion|
|positive regulation of MAP kinase activity|
|negative regulation of cytokine production|
|regulation of leukocyte cell-cell adhesion|
|response to light stimulus|
|response to lipopolysaccharide|
|negative regulation of locomotion|
|response to molecule of bacterial origin|
|phagocytosis|
|defense response to bacterium|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|extracellular matrix organization|
|regulation of MAP kinase activity|
|humoral immune response|
|negative regulation of response to external stimulus|
|collagen-containing extracellular matrix|
|leukocyte migration|
|extracellular structure organization|
|regulation of cell-cell adhesion|
|cellular component disassembly|
|positive regulation of cell adhesion|
|peptide biosynthetic process|
|cellular calcium ion homeostasis|
|response to radiation|
|positive regulation of cytokine production|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|neutrophil degranulation|
|divalent inorganic cation homeostasis|
|neutrophil activation involved in immune response|
|inflammatory response|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|amide biosynthetic process|
|peptide metabolic process|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|cell surface|
|metal ion homeostasis|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular cation homeostasis|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|regulation of cell adhesion|
|protein catabolic process|
|response to bacterium|
|regulation of cytokine production|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|regulation of defense response|
|leukocyte mediated immunity|
|symbiotic process|
|ion homeostasis|
|cellular amide metabolic process|
|exocytosis|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of cell migration|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|regulation of kinase activity|
|cellular homeostasis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|leukocyte activation|
|defense response to other organism|
|cell migration|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10545
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ELANE Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>