ELF5 [The Human Chemical-Genetic Interaction Map Project]

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======= ELF5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ELF5
  * **<color #00a2e8>Official Name</color>**: E74 like ETS transcription factor 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2001|2001]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKW6|Q9UKW6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ELF5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ELF5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605169|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. {ECO:0000269|PubMed:10506207}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ets|
|SAM PNT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ectodermal cell fate commitment|
|ectoderm formation|
|ectodermal cell differentiation|
|mammary gland epithelial cell differentiation|
|ectoderm development|
|cell fate commitment involved in formation of primary germ layer|
|mammary gland epithelium development|
|somatic stem cell population maintenance|
|formation of primary germ layer|
|mammary gland development|
|stem cell population maintenance|
|maintenance of cell number|
|gastrulation|
|cell fate commitment|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|gland development|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|embryonic morphogenesis|
|epithelial cell differentiation|
|negative regulation of cell differentiation|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|embryo development|
|epithelium development|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13129
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ELF5 Expression in NALM6 Cells: 1.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>