ELL3 [The Human Chemical-Genetic Interaction Map Project]

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======= ELL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ELL3
  * **<color #00a2e8>Official Name</color>**: elongation factor for RNA polymerase II 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80237|80237]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HB65|Q9HB65]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ELL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ELL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609885|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Occludin ELL|
|ELL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|enhancer binding|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|transcription elongation factor complex|
|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|positive regulation of DNA-templated transcription, elongation|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|negative regulation of signal transduction by p53 class mediator|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of DNA-templated transcription, elongation|
|positive regulation of neural precursor cell proliferation|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|transcription elongation from RNA polymerase II promoter|
|negative regulation of response to DNA damage stimulus|
|regulation of epithelial to mesenchymal transition|
|regulation of neural precursor cell proliferation|
|DNA-templated transcription, elongation|
|ncRNA transcription|
|negative regulation of intrinsic apoptotic signaling pathway|
|stem cell differentiation|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of signal transduction by p53 class mediator|
|regulation of response to DNA damage stimulus|
|negative regulation of apoptotic signaling pathway|
|regulation of apoptotic signaling pathway|
|positive regulation of neurogenesis|
|transcription by RNA polymerase II|
|negative regulation of intracellular signal transduction|
|positive regulation of nervous system development|
|positive regulation of cell development|
|spermatogenesis|
|male gamete generation|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|gamete generation|
|regulation of cellular response to stress|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|nucleolus|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|multi-organism reproductive process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.93|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3722
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ELL3 Expression in NALM6 Cells: 3.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>