ELP6 [The Human Chemical-Genetic Interaction Map Project]

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======= ELP6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ELP6
  * **<color #00a2e8>Official Name</color>**: elongator acetyltransferase complex subunit 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54859|54859]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q0PNE2|Q0PNE2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ELP6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ELP6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615020|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2348|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Elongator holoenzyme complex|
|tRNA wobble uridine modification|
|tRNA wobble base modification|
|tRNA modification|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|ncRNA processing|
|ncRNA metabolic process|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|molecular function|
|regulation of cell migration|
|RNA processing|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.91|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.74|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.73|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.74|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.86|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.88|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.9|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.97|
|[[:results:exp495|IWR1 50μM R08 exp495]]|1.99|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.99|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.04|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.17|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.27|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.38|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.45|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.58|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.98|
|[[:results:exp134|MS023 2μM R03 exp134]]|3|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|3.06|
|[[:results:exp135|MS023 7μM R03 exp135]]|3.66|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|4.1|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|4.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kti12|KTI12]]|0.773|
|[[:human genes:e:elp3|ELP3]]|0.734|
|[[:human genes:c:ctu1|CTU1]]|0.722|
|[[:human genes:e:elp2|ELP2]]|0.712|
|[[:human genes:u:urm1|URM1]]|0.709|
|[[:human genes:m:mocs3|MOCS3]]|0.706|
|[[:human genes:d:dph3|DPH3]]|0.653|
|[[:human genes:c:ctu2|CTU2]]|0.647|
|[[:human genes:e:elp4|ELP4]]|0.628|
|[[:human genes:e:elp5|ELP5]]|0.613|
|[[:human genes:n:nr2c2ap|NR2C2AP]]|0.57|
|[[:human genes:i:ikbkap|IKBKAP]]|0.563|
|[[:human genes:f:fam98b|FAM98B]]|0.516|
|[[:human genes:d:dhrsx|DHRSX]]|0.493|
|[[:human genes:d:dph1|DPH1]]|0.487|
|[[:human genes:p:pmvk|PMVK]]|0.483|
|[[:human genes:f:fh|FH]]|0.468|
|[[:human genes:r:rpp21|RPP21]]|0.467|
|[[:human genes:m:msto1|MSTO1]]|0.454|
|[[:human genes:s:ssb|SSB]]|0.45|
|[[:human genes:p:pgm3|PGM3]]|0.448|
|[[:human genes:k:kmt2d|KMT2D]]|0.444|
|[[:human genes:t:thg1l|THG1L]]|0.444|
|[[:human genes:a:atic|ATIC]]|0.44|
|[[:human genes:k:kdsr|KDSR]]|0.433|
|[[:human genes:g:gemin6|GEMIN6]]|0.433|
|[[:human genes:a:alkbh8|ALKBH8]]|0.43|
|[[:human genes:k:kdm8|KDM8]]|0.429|
|[[:human genes:d:dph5|DPH5]]|0.424|
|[[:human genes:t:tkt|TKT]]|0.424|
|[[:human genes:d:dnlz|DNLZ]]|0.423|
|[[:human genes:p:pdap1|PDAP1]]|0.422|
|[[:human genes:g:g6pd|G6PD]]|0.422|
|[[:human genes:s:slc7a1|SLC7A1]]|0.42|
|[[:human genes:d:dph2|DPH2]]|0.419|
|[[:human genes:s:sbds|SBDS]]|0.419|
|[[:human genes:a:atxn10|ATXN10]]|0.416|
|[[:human genes:c:c7orf26|C7orf26]]|0.416|
|[[:human genes:d:dohh|DOHH]]|0.416|
|[[:human genes:p:ppcdc|PPCDC]]|0.415|
|[[:human genes:p:ptar1|PTAR1]]|0.414|
|[[:human genes:d:ddx1|DDX1]]|0.412|
|[[:human genes:r:rabggtb|RABGGTB]]|0.403|
|[[:human genes:e:eef1e1|EEF1E1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 631/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|23/28|
|bone|21/26|
|breast|21/33|
|central nervous system|50/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|20/21|
|liver|19/20|
|lung|62/75|
|lymphocyte|10/16|
|ovary|23/26|
|pancreas|21/24|
|peripheral nervous system|13/16|
|plasma cell|8/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 814
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ELP6 Expression in NALM6 Cells: 5.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>