ELSPBP1 [The Human Chemical-Genetic Interaction Map Project]

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======= ELSPBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ELSPBP1
  * **<color #00a2e8>Official Name</color>**: epididymal sperm binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64100|64100]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96BH3|Q96BH3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ELSPBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ELSPBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607443|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|fn2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sperm capacitation|
|single fertilization|
|spermatid development|
|spermatid differentiation|
|cell maturation|
|heparin binding|
|fertilization|
|developmental maturation|
|germ cell development|
|cellular process involved in reproduction in multicellular organism|
|spermatogenesis|
|male gamete generation|
|cell surface|
|developmental process involved in reproduction|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|reproductive process|
|reproduction|
|cell development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-2.65|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.97|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.84|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.72|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.73|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.79|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.8|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.81|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.88|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.88|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.93|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.02|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.13|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8807
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ELSPBP1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>