EMC3 [The Human Chemical-Genetic Interaction Map Project]

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======= EMC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EMC3
  * **<color #00a2e8>Official Name</color>**: ER membrane protein complex subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55831|55831]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P0I2|Q9P0I2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EMC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EMC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620273|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF106|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ER membrane protein complex|
|protein folding in endoplasmic reticulum|
|protein folding|
|molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.17|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.09|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.05|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.92|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.79|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:emc2|EMC2]]|0.552|
|[[:human genes:e:emc1|EMC1]]|0.475|
|[[:human genes:m:mmgt1|MMGT1]]|0.464|
|[[:human genes:e:emc4|EMC4]]|0.441|
|[[:human genes:e:emc6|EMC6]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 543/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|18/28|
|blood|26/28|
|bone|21/26|
|breast|17/33|
|central nervous system|43/56|
|cervix|2/4|
|colorectal|9/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|20/21|
|liver|12/20|
|lung|49/75|
|lymphocyte|13/16|
|ovary|18/26|
|pancreas|21/24|
|peripheral nervous system|14/16|
|plasma cell|14/15|
|prostate|0/1|
|skin|18/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|15/22|
|urinary tract|20/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 721
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EMC3 Expression in NALM6 Cells: 5.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>