EMC6 [The Human Chemical-Genetic Interaction Map Project]

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======= EMC6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EMC6
  * **<color #00a2e8>Official Name</color>**: ER membrane protein complex subunit 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83460|83460]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BV81|Q9BV81]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EMC6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EMC6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620261|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rab5ip|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integral component of omegasome membrane|
|ER membrane protein complex|
|protein folding in endoplasmic reticulum|
|autophagosome assembly|
|autophagosome organization|
|integral component of endoplasmic reticulum membrane|
|vacuole organization|
|macroautophagy|
|protein folding|
|process utilizing autophagic mechanism|
|autophagy|
|organelle assembly|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.84|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.79|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.79|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.7|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.83|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.94|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.94|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mmgt1|MMGT1]]|0.603|
|[[:human genes:e:emc2|EMC2]]|0.525|
|[[:human genes:e:emc4|EMC4]]|0.452|
|[[:human genes:e:emc1|EMC1]]|0.416|
|[[:human genes:e:emc3|EMC3]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|5/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2446
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EMC6 Expression in NALM6 Cells: 3.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>