ENO3 [The Human Chemical-Genetic Interaction Map Project]

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======= ENO3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ENO3
  * **<color #00a2e8>Official Name</color>**: enolase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2027|2027]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13929|P13929]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ENO3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ENO3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/131370|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Appears to have a function in striated muscle development and regeneration.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Enolase N|
|Enolase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphopyruvate hydratase activity|
|phosphopyruvate hydratase complex|
|canonical glycolysis|
|glucose catabolic process to pyruvate|
|NADH regeneration|
|glycolytic process through fructose-6-phosphate|
|glycolytic process through glucose-6-phosphate|
|glucose catabolic process|
|skeletal muscle tissue regeneration|
|NADH metabolic process|
|glycolytic process|
|ATP generation from ADP|
|gluconeogenesis|
|NAD metabolic process|
|hexose biosynthetic process|
|ADP metabolic process|
|hexose catabolic process|
|monosaccharide biosynthetic process|
|nucleoside diphosphate phosphorylation|
|monosaccharide catabolic process|
|purine nucleoside diphosphate metabolic process|
|nucleotide phosphorylation|
|purine ribonucleoside diphosphate metabolic process|
|tissue regeneration|
|ribonucleoside diphosphate metabolic process|
|pyruvate metabolic process|
|nucleoside diphosphate metabolic process|
|glucose metabolic process|
|carbohydrate catabolic process|
|carbohydrate biosynthetic process|
|hexose metabolic process|
|regeneration|
|monosaccharide metabolic process|
|ATP metabolic process|
|magnesium ion binding|
|aging|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|developmental growth|
|growth|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|carbohydrate metabolic process|
|wound healing|
|protein heterodimerization activity|
|monocarboxylic acid metabolic process|
|nucleobase-containing small molecule metabolic process|
|response to wounding|
|small molecule biosynthetic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|phosphorylation|
|extracellular space|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6177
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ENO3 Expression in NALM6 Cells: 4.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>