ENPP4 [The Human Chemical-Genetic Interaction Map Project]

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======= ENPP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ENPP4
  * **<color #00a2e8>Official Name</color>**: ectonucleotide pyrophosphatase/phosphodiesterase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22875|22875]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6X5|Q9Y6X5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ENPP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ENPP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617000|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors. {ECO:0000269|PubMed:22995898, ECO:0000269|PubMed:24338010}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Phosphodiest|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|bis(5-adenosyl)-triphosphatase activity|
|purine ribonucleoside catabolic process|
|purine nucleoside catabolic process|
|ribonucleoside catabolic process|
|positive regulation of blood coagulation|
|positive regulation of hemostasis|
|positive regulation of coagulation|
|nucleoside catabolic process|
|glycosyl compound catabolic process|
|nucleobase-containing small molecule catabolic process|
|purine-containing compound catabolic process|
|positive regulation of wound healing|
|ficolin-1-rich granule membrane|
|purine ribonucleoside metabolic process|
|positive regulation of response to wounding|
|purine nucleoside metabolic process|
|ribonucleoside metabolic process|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|nucleoside metabolic process|
|glycosyl compound metabolic process|
|regulation of wound healing|
|regulation of response to wounding|
|carbohydrate derivative catabolic process|
|blood coagulation|
|coagulation|
|hemostasis|
|purine-containing compound metabolic process|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|wound healing|
|organic cyclic compound catabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|nucleobase-containing small molecule metabolic process|
|response to wounding|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|leukocyte activation|
|secretion by cell|
|carbohydrate derivative metabolic process|
|export from cell|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|regulation of response to stress|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.7|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.75|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.75|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.89|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|2.17|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16320
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ENPP4 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>