EOMES [The Human Chemical-Genetic Interaction Map Project]

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======= EOMES =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EOMES
  * **<color #00a2e8>Official Name</color>**: eomesodermin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8320|8320]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95936|O95936]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EOMES&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EOMES|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604615|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. {ECO:0000269|PubMed:17353897, ECO:0000269|PubMed:17566017}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|T-box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CD8-positive, alpha-beta T cell differentiation involved in immune response|
|mesodermal to mesenchymal transition involved in gastrulation|
|endodermal cell fate specification|
|cerebral cortex regionalization|
|CD8-positive, alpha-beta T cell differentiation|
|mesendoderm development|
|CD8-positive, alpha-beta T cell activation|
|cardioblast differentiation|
|endodermal cell fate commitment|
|telencephalon regionalization|
|trophectodermal cell differentiation|
|interferon-gamma production|
|cerebral cortex neuron differentiation|
|forebrain regionalization|
|cell differentiation involved in embryonic placenta development|
|alpha-beta T cell differentiation involved in immune response|
|cell fate commitment involved in formation of primary germ layer|
|alpha-beta T cell activation involved in immune response|
|T cell differentiation involved in immune response|
|olfactory bulb development|
|olfactory lobe development|
|blastocyst formation|
|endodermal cell differentiation|
|endoderm formation|
|alpha-beta T cell differentiation|
|skeletal muscle cell differentiation|
|RNA polymerase II activating transcription factor binding|
|alpha-beta T cell activation|
|T cell activation involved in immune response|
|mesoderm formation|
|mesoderm morphogenesis|
|epithelial to mesenchymal transition|
|endoderm development|
|embryonic placenta development|
|cell fate specification|
|blastocyst development|
|lymphocyte activation involved in immune response|
|formation of primary germ layer|
|cardiocyte differentiation|
|cerebral cortex development|
|skeletal muscle tissue development|
|mesoderm development|
|skeletal muscle organ development|
|T cell differentiation|
|stem cell population maintenance|
|maintenance of cell number|
|cytokine production|
|placenta development|
|mesenchymal cell differentiation|
|stem cell differentiation|
|gastrulation|
|negative regulation of DNA-binding transcription factor activity|
|pallium development|
|central nervous system neuron differentiation|
|mesenchyme development|
|T cell activation|
|lymphocyte differentiation|
|nuclear chromatin|
|cell fate commitment|
|telencephalon development|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|leukocyte differentiation|
|regionalization|
|in utero embryonic development|
|lymphocyte activation|
|forebrain development|
|chromatin binding|
|sequence-specific DNA binding|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|muscle structure development|
|heart development|
|hemopoiesis|
|tissue morphogenesis|
|embryonic morphogenesis|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|brain development|
|head development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|leukocyte activation|
|embryo development|
|central nervous system development|
|neuron differentiation|
|cell activation|
|immune effector process|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.72|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9494
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EOMES Expression in NALM6 Cells: -2.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>