EP300 [The Human Chemical-Genetic Interaction Map Project]

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======= EP300 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EP300
  * **<color #00a2e8>Official Name</color>**: E1A binding protein p300
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2033|2033]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q09472|Q09472]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EP300&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EP300|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602700|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (PubMed:23911289). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA) or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation or propionylation, respectively (PubMed:25818647, PubMed:17267393). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (E)-but-2-enoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KAT11|
|KIX|
|zf-TAZ|
|DUF902|
|Bromodomain|
|Creb binding|
|ZZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptidyl-lysine butyrylation|
|histone crotonyltransferase activity|
|peptide butyryltransferase activity|
|protein propionyltransferase activity|
|swimming|
|histone butyryltransferase activity|
|peptidyl-lysine crotonylation|
|peptidyl-lysine propionylation|
|positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding|
|thigmotaxis|
|N-terminal peptidyl-lysine acetylation|
|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|
|histone H2B acetylation|
|peptide-lysine-N-acetyltransferase activity|
|lysine N-acetyltransferase activity, acting on acetyl phosphate as donor|
|macrophage derived foam cell differentiation|
|foam cell differentiation|
|pre-mRNA intronic binding|
|STAT family protein binding|
|regulation of tubulin deacetylation|
|regulation of RNA polymerase II regulatory region sequence-specific DNA binding|
|N-terminal protein amino acid acetylation|
|megakaryocyte development|
|negative regulation of gluconeogenesis|
|positive regulation by host of viral transcription|
|negative regulation of protein oligomerization|
|acetyltransferase activity|
|positive regulation of transcription of Notch receptor target|
|platelet formation|
|platelet morphogenesis|
|megakaryocyte differentiation|
|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|
|transferase activity, transferring acyl groups|
|positive regulation of transcription regulatory region DNA binding|
|bone cell development|
|nuclear hormone receptor binding|
|regulation of androgen receptor signaling pathway|
|N-terminal protein amino acid modification|
|histone acetyltransferase complex|
|beta-catenin-TCF complex assembly|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|NF-kappaB binding|
|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|behavioral defense response|
|face morphogenesis|
|activating transcription factor binding|
|head morphogenesis|
|positive regulation of viral transcription|
|negative regulation of cellular carbohydrate metabolic process|
|regulation of protein deacetylation|
|regulation of protein oligomerization|
|androgen receptor binding|
|protein-DNA complex|
|tau protein binding|
|regulation of gluconeogenesis|
|body morphogenesis|
|protein destabilization|
|face development|
|negative regulation of carbohydrate metabolic process|
|histone acetyltransferase activity|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|regulation of transcription regulatory region DNA binding|
|positive regulation of Notch signaling pathway|
|RNA polymerase II activating transcription factor binding|
|regulation of megakaryocyte differentiation|
|histone H4 acetylation|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|positive regulation of DNA binding|
|damaged DNA binding|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|myeloid cell development|
|RNA polymerase II transcription factor binding|
|mitotic G1 DNA damage checkpoint|
|positive regulation of gene expression, epigenetic|
|mitotic G1/S transition checkpoint|
|regulation of viral transcription|
|G1 DNA damage checkpoint|
|somitogenesis|
|p53 binding|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|signal transduction involved in DNA integrity checkpoint|
|chromatin DNA binding|
|signal transduction involved in DNA damage checkpoint|
|modification by host of symbiont morphology or physiology|
|signal transduction involved in cell cycle checkpoint|
|transcription-coupled nucleotide-excision repair|
|response to estrogen|
|interaction with symbiont|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of intracellular steroid hormone receptor signaling pathway|
|positive regulation of type I interferon production|
|DNA damage response, signal transduction by p53 class mediator|
|regulation of cellular response to heat|
|positive regulation of cell cycle arrest|
|somite development|
|multicellular organism growth|
|beta-catenin binding|
|cellular response to UV|
|negative regulation of small molecule metabolic process|
|positive regulation of protein binding|
|regulation of carbohydrate biosynthetic process|
|mitotic DNA damage checkpoint|
|segmentation|
|regulation of Notch signaling pathway|
|negative regulation of G1/S transition of mitotic cell cycle|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|endoplasmic reticulum unfolded protein response|
|negative regulation of cell cycle G1/S phase transition|
|fat cell differentiation|
|regulation of cell cycle arrest|
|B cell differentiation|
|positive regulation of viral process|
|regulation of NIK/NF-kappaB signaling|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|nucleotide-excision repair|
|stimulatory C-type lectin receptor signaling pathway|
|cellular response to light stimulus|
|histone acetylation|
|regulation of glucose metabolic process|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|innate immune response activating cell surface receptor signaling pathway|
|internal peptidyl-lysine acetylation|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|signal transduction by p53 class mediator|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|chromosome|
|skeletal muscle tissue development|
|regulation of DNA-templated transcription in response to stress|
|regulation of DNA binding|
|Notch signaling pathway|
|regulation of type I interferon production|
|cellular response to unfolded protein|
|negative regulation of protein complex assembly|
|DNA damage checkpoint|
|skeletal muscle organ development|
|regulation of cellular carbohydrate metabolic process|
|circadian rhythm|
|response to UV|
|protein acetylation|
|DNA integrity checkpoint|
|intrinsic apoptotic signaling pathway|
|cellular response to topologically incorrect protein|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|B cell activation|
|modification of morphology or physiology of other organism|
|response to unfolded protein|
|regulation of cell cycle G1/S phase transition|
|lung development|
|respiratory tube development|
|cellular response to radiation|
|positive regulation of binding|
|protein stabilization|
|regulation of signal transduction by p53 class mediator|
|response to topologically incorrect protein|
|protein acylation|
|cellular response to hypoxia|
|protein C-terminus binding|
|cell cycle checkpoint|
|respiratory system development|
|cellular response to decreased oxygen levels|
|bone development|
|regulation of carbohydrate metabolic process|
|regulation of viral process|
|transcription factor complex|
|negative regulation of mitotic cell cycle phase transition|
|cellular response to oxygen levels|
|anterior/posterior pattern specification|
|regulation of protein binding|
|myeloid cell differentiation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|protein maturation|
|regulation of myeloid cell differentiation|
|negative regulation of cell cycle phase transition|
|innate immune response-activating signal transduction|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of gene expression, epigenetic|
|lymphocyte differentiation|
|response to endoplasmic reticulum stress|
|activation of innate immune response|
|learning or memory|
|positive regulation of DNA-binding transcription factor activity|
|regulation of cellular response to growth factor stimulus|
|rhythmic process|
|positive regulation of neuron projection development|
|protein deubiquitination|
|striated muscle tissue development|
|transcription coactivator activity|
|apoptotic signaling pathway|
|positive regulation of cell cycle process|
|regulation of protein stability|
|muscle organ development|
|muscle tissue development|
|protein modification by small protein removal|
|cognition|
|response to light stimulus|
|negative regulation of mitotic cell cycle|
|peptidyl-lysine modification|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|negative regulation of cell cycle process|
|leukocyte differentiation|
|regulation of autophagy|
|regionalization|
|transcription factor binding|
|positive regulation of innate immune response|
|response to hypoxia|
|response to decreased oxygen levels|
|positive regulation of response to biotic stimulus|
|histone modification|
|positive regulation of neuron differentiation|
|covalent chromatin modification|
|regulation of binding|
|positive regulation of cell cycle|
|response to oxygen levels|
|positive regulation of cell projection organization|
|lymphocyte activation|
|developmental growth|
|growth|
|chromatin binding|
|regulation of mitotic cell cycle phase transition|
|regulation of small molecule metabolic process|
|regulation of DNA-binding transcription factor activity|
|pattern specification process|
|response to radiation|
|regulation of cell cycle phase transition|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of cytokine production|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|regulation of protein complex assembly|
|regulation of innate immune response|
|positive regulation of neurogenesis|
|positive regulation of defense response|
|muscle structure development|
|immune response-regulating cell surface receptor signaling pathway|
|skeletal system development|
|regulation of neuron projection development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|DNA repair|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|heart development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|taxis|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|immune response-activating signal transduction|
|behavior|
|negative regulation of cell cycle|
|immune response-regulating signaling pathway|
|mitotic cell cycle process|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|activation of immune response|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|regulation of neuron differentiation|
|mitotic cell cycle|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cytokine production|
|chromatin organization|
|viral process|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|cell morphogenesis|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of cell cycle process|
|regulation of defense response|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|head development|
|symbiotic process|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|zinc ion binding|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|circulatory system development|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|apoptotic process|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|embryo development|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|cell cycle process|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|chromosome organization|
|cell activation|
|cell death|
|regulation of response to external stimulus|
|epithelium development|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|locomotion|
|negative regulation of RNA metabolic process|
|cell cycle|
|defense response|
|positive regulation of developmental process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.89|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-2.85|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.76|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.64|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.53|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.46|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.45|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.32|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.18|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.14|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.11|
|[[:results:exp135|MS023 7μM R03 exp135]]|-2.01|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.99|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.99|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.98|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.96|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.92|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.91|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.89|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.88|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.88|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.86|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.85|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.84|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.81|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.76|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.71|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.7|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.73|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.75|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.77|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.83|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.84|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.85|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.88|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|2.14|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.28|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.596|
|[[:human genes:p:polr2j3|POLR2J3]]|0.547|
|[[:human genes:m:myb|MYB]]|0.403|
|[[:human genes:h:h3f3a|H3F3A]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 67/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|6/28|
|bone|0/25|
|breast|6/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|1/21|
|liver|2/20|
|lung|2/75|
|lymphocyte|7/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 469
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EP300 Expression in NALM6 Cells: 7.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>