EP400 [The Human Chemical-Genetic Interaction Map Project]

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======= EP400 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EP400
  * **<color #00a2e8>Official Name</color>**: E1A binding protein p400
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57634|57634]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96L91|Q96L91]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EP400&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EP400|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606265|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNF2 N|
|HSA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein antigen binding|
|Swr1 complex|
|histone H2A acetylation|
|NuA4 histone acetyltransferase complex|
|helicase activity|
|histone H4 acetylation|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|protein acylation|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|chromatin binding|
|nuclear speck|
|chromatin organization|
|peptidyl-amino acid modification|
|chromosome organization|
|DNA binding|
|ATP binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-2.21|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.96|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.71|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.76|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.81|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|2|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.18|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.491|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 528/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|20/28|
|blood|25/28|
|bone|16/25|
|breast|22/33|
|central nervous system|41/56|
|cervix|4/4|
|colorectal|11/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|8/15|
|kidney|10/21|
|liver|15/20|
|lung|55/75|
|lymphocyte|13/14|
|ovary|23/26|
|pancreas|21/24|
|peripheral nervous system|15/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|16/24|
|soft tissue|5/7|
|thyroid|1/2|
|upper aerodigestive|14/22|
|urinary tract|15/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2320
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EP400 Expression in NALM6 Cells: 7.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>