EPB41L5 [The Human Chemical-Genetic Interaction Map Project]

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======= EPB41L5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPB41L5
  * **<color #00a2e8>Official Name</color>**: erythrocyte membrane protein band 4.1 like 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57669|57669]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HCM4|Q9HCM4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPB41L5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPB41L5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611730|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FERM M|
|FERM N|
|FERM C|
|FA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|unidimensional cell growth|
|axial mesoderm morphogenesis|
|substrate-dependent cell migration, cell attachment to substrate|
|apical constriction|
|mesoderm migration involved in gastrulation|
|mesodermal cell migration|
|neural plate morphogenesis|
|axial mesoderm development|
|embryonic foregut morphogenesis|
|foregut morphogenesis|
|neural plate development|
|somite rostral/caudal axis specification|
|left/right axis specification|
|cell migration involved in gastrulation|
|paraxial mesoderm development|
|ectoderm development|
|left/right pattern formation|
|positive regulation of focal adhesion assembly|
|substrate-dependent cell migration|
|positive regulation of adherens junction organization|
|positive regulation of cell junction assembly|
|epithelial cell morphogenesis|
|embryonic axis specification|
|digestive tract morphogenesis|
|anterior/posterior axis specification|
|positive regulation of cell-matrix adhesion|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|embryonic pattern specification|
|somitogenesis|
|mesoderm formation|
|regulation of adherens junction organization|
|mesoderm morphogenesis|
|epithelial to mesenchymal transition|
|endoderm development|
|cytoskeletal protein binding|
|somite development|
|axis specification|
|regulation of cell junction assembly|
|actin-mediated cell contraction|
|cell growth|
|positive regulation of protein binding|
|tissue migration|
|ruffle membrane|
|segmentation|
|negative regulation of protein binding|
|actin filament-based movement|
|formation of primary germ layer|
|developmental growth involved in morphogenesis|
|actomyosin structure organization|
|regulation of cell-matrix adhesion|
|positive regulation of cell-substrate adhesion|
|mesoderm development|
|digestive tract development|
|positive regulation of epithelial cell migration|
|digestive system development|
|morphogenesis of embryonic epithelium|
|cellular response to transforming growth factor beta stimulus|
|mesenchymal cell differentiation|
|gastrulation|
|response to transforming growth factor beta|
|negative regulation of binding|
|ameboidal-type cell migration|
|negative regulation of cell-cell adhesion|
|positive regulation of binding|
|cell-substrate adhesion|
|epithelial cell development|
|regulation of cell-substrate adhesion|
|anterior/posterior pattern specification|
|regulation of protein binding|
|regulation of epithelial cell migration|
|mesenchyme development|
|protein domain specific binding|
|negative regulation of cell adhesion|
|regionalization|
|cytoskeleton|
|regulation of binding|
|in utero embryonic development|
|developmental growth|
|growth|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|focal adhesion|
|morphogenesis of an epithelium|
|pattern specification process|
|actin cytoskeleton organization|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|posttranscriptional regulation of gene expression|
|response to growth factor|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|actin filament-based process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|epithelial cell differentiation|
|regulation of cell adhesion|
|cell morphogenesis|
|regulation of establishment of protein localization|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|cell migration|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of protein localization|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|epithelium development|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|locomotion|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13938
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPB41L5 Expression in NALM6 Cells: 4.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>