EPHA8 [The Human Chemical-Genetic Interaction Map Project]

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======= EPHA8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPHA8
  * **<color #00a2e8>Official Name</color>**: EPH receptor A8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2046|2046]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29322|P29322]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPHA8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPHA8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176945|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAM 1|
|fn3|
|Pkinase|
|Ephrin lbd|
|SAM 2|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GPI-linked ephrin receptor activity|
|cellular response to follicle-stimulating hormone stimulus|
|neuron remodeling|
|response to follicle-stimulating hormone|
|transmembrane-ephrin receptor activity|
|cellular response to gonadotropin stimulus|
|substrate-dependent cell migration|
|response to gonadotropin|
|positive regulation of phosphatidylinositol 3-kinase activity|
|positive regulation of lipid kinase activity|
|neuron maturation|
|regulation of cell adhesion mediated by integrin|
|positive regulation of phospholipid metabolic process|
|regulation of phosphatidylinositol 3-kinase activity|
|transmembrane receptor protein tyrosine kinase activity|
|regulation of lipid kinase activity|
|regulation of phospholipid metabolic process|
|ephrin receptor signaling pathway|
|anatomical structure maturation|
|positive regulation of lipid metabolic process|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|early endosome membrane|
|cell maturation|
|protein autophosphorylation|
|receptor complex|
|developmental maturation|
|axon guidance|
|neuron projection guidance|
|neuron projection|
|axonogenesis|
|regulation of lipid metabolic process|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|positive regulation of kinase activity|
|cellular response to hormone stimulus|
|positive regulation of transferase activity|
|neuron projection development|
|regulation of cell adhesion|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of MAPK cascade|
|neuron development|
|cellular component morphogenesis|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|response to hormone|
|cell adhesion|
|biological adhesion|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|locomotion|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-2.07|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.89|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.87|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.82|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.77|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11303
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPHA8 Expression in NALM6 Cells: -2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>