EPHB1 [The Human Chemical-Genetic Interaction Map Project]

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======= EPHB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPHB1
  * **<color #00a2e8>Official Name</color>**: EPH receptor B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2047|2047]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54762|P54762]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPHB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPHB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600600|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). {ECO:0000250|UniProtKB:Q8CBF3, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:12925710, ECO:0000269|PubMed:18034775, ECO:0000269|PubMed:9430661, ECO:0000269|PubMed:9499402}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|fn3|
|Pkinase|
|Ephrin lbd|
|SAM 2|
|Pkinase Tyr|
|SAM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of skeletal muscle satellite cell proliferation|
|skeletal muscle satellite cell activation|
|negative regulation of skeletal muscle cell proliferation|
|negative regulation of satellite cell differentiation|
|negative regulation of skeletal muscle cell differentiation|
|optic nerve morphogenesis|
|axon guidance receptor activity|
|negative regulation of skeletal muscle tissue development|
|regulation of skeletal muscle satellite cell proliferation|
|optic nerve development|
|immunological synapse formation|
|regulation of skeletal muscle cell proliferation|
|detection of temperature stimulus involved in sensory perception of pain|
|detection of temperature stimulus involved in sensory perception|
|transmembrane-ephrin receptor activity|
|dendritic spine morphogenesis|
|filopodium tip|
|detection of temperature stimulus|
|retinal ganglion cell axon guidance|
|regulation of skeletal muscle cell differentiation|
|sensory perception of temperature stimulus|
|central nervous system projection neuron axonogenesis|
|dendritic spine development|
|cranial nerve morphogenesis|
|dendritic spine organization|
|central nervous system neuron axonogenesis|
|neuron projection organization|
|negative regulation of striated muscle tissue development|
|negative regulation of muscle organ development|
|regulation of skeletal muscle tissue development|
|negative regulation of muscle tissue development|
|cranial nerve development|
|transmembrane receptor protein tyrosine kinase activity|
|dendrite morphogenesis|
|positive regulation of synapse assembly|
|cell-cell recognition|
|sensory perception of pain|
|neural precursor cell proliferation|
|nerve development|
|central nervous system neuron development|
|ephrin receptor signaling pathway|
|postsynapse organization|
|dendrite development|
|regulation of synapse assembly|
|camera-type eye morphogenesis|
|establishment of cell polarity|
|detection of external stimulus|
|detection of abiotic stimulus|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|peptidyl-tyrosine phosphorylation|
|eye morphogenesis|
|peptidyl-tyrosine modification|
|early endosome membrane|
|response to temperature stimulus|
|central nervous system neuron differentiation|
|cell-substrate adhesion|
|regulation of JNK cascade|
|protein autophosphorylation|
|establishment or maintenance of cell polarity|
|receptor complex|
|cell chemotaxis|
|regulation of synapse organization|
|membrane raft|
|regulation of synapse structure or activity|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|cell recognition|
|sensory organ morphogenesis|
|axon guidance|
|neuron projection guidance|
|protein-containing complex binding|
|synapse organization|
|regulation of ERK1 and ERK2 cascade|
|axon|
|regulation of neuron death|
|camera-type eye development|
|angiogenesis|
|neuron projection|
|glutamatergic synapse|
|eye development|
|visual system development|
|sensory system development|
|axonogenesis|
|lymphocyte activation|
|blood vessel morphogenesis|
|axon development|
|dendrite|
|cell morphogenesis involved in neuron differentiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|detection of stimulus involved in sensory perception|
|sensory organ development|
|chemotaxis|
|taxis|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|tube morphogenesis|
|neuron projection development|
|negative regulation of cell population proliferation|
|detection of stimulus|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|neuron development|
|cellular component morphogenesis|
|tube development|
|circulatory system development|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|sensory perception|
|protein phosphorylation|
|central nervous system development|
|endoplasmic reticulum|
|neuron differentiation|
|cell activation|
|localization of cell|
|cell motility|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|phosphorylation|
|locomotion|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10024
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPHB1 Expression in NALM6 Cells: 0.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>