EPHB2 [The Human Chemical-Genetic Interaction Map Project]

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======= EPHB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPHB2
  * **<color #00a2e8>Official Name</color>**: EPH receptor B2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2048|2048]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29323|P29323]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPHB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPHB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600997|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. {ECO:0000269|PubMed:15300251}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAM 1|
|Ephrin lbd|
|SAM 2|
|Pkinase Tyr|
|fn3|
|GCC2 GCC3|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuron projection retraction|
|negative regulation of NMDA glutamate receptor activity|
|inactivation of MAPKK activity|
|negative regulation of glutamate receptor signaling pathway|
|trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission|
|positive regulation of long-term neuronal synaptic plasticity|
|optic nerve morphogenesis|
|positive regulation of NMDA glutamate receptor activity|
|trans-synaptic signaling by trans-synaptic complex|
|axon guidance receptor activity|
|positive regulation of synaptic plasticity|
|postsynaptic membrane assembly|
|trans-synaptic signaling, modulating synaptic transmission|
|commissural neuron axon guidance|
|optic nerve development|
|positive regulation of glutamate receptor signaling pathway|
|corpus callosum development|
|transmembrane-ephrin receptor activity|
|dendritic spine morphogenesis|
|postsynapse assembly|
|retinal ganglion cell axon guidance|
|positive regulation of long-term synaptic potentiation|
|axonal fasciculation|
|neuron projection fasciculation|
|central nervous system projection neuron axonogenesis|
|regulation of long-term neuronal synaptic plasticity|
|postsynaptic membrane organization|
|cranial nerve morphogenesis|
|dendritic spine development|
|dendritic spine organization|
|positive regulation of signaling receptor activity|
|membrane assembly|
|central nervous system neuron axonogenesis|
|regulation of NMDA receptor activity|
|membrane biogenesis|
|neuron projection organization|
|negative regulation of cation channel activity|
|regulation of long-term synaptic potentiation|
|integral component of postsynaptic membrane|
|neuron recognition|
|cranial nerve development|
|negative regulation of Ras protein signal transduction|
|regulation of neuronal synaptic plasticity|
|transmembrane receptor protein tyrosine kinase activity|
|positive regulation of protein localization to plasma membrane|
|dendrite morphogenesis|
|integral component of presynaptic membrane|
|negative regulation of signaling receptor activity|
|negative regulation of small GTPase mediated signal transduction|
|positive regulation of protein localization to cell periphery|
|regulation of glutamate receptor signaling pathway|
|positive regulation of synapse assembly|
|negative regulation of ERK1 and ERK2 cascade|
|positive regulation of cation channel activity|
|negative regulation of axonogenesis|
|negative regulation of ion transmembrane transporter activity|
|regulation of neurotransmitter receptor activity|
|negative regulation of transporter activity|
|nerve development|
|central nervous system neuron development|
|amyloid-beta binding|
|negative regulation of cation transmembrane transport|
|postsynapse|
|ephrin receptor signaling pathway|
|postsynapse organization|
|protein tyrosine kinase activity|
|roof of mouth development|
|synapse assembly|
|regulation of protein localization to plasma membrane|
|negative regulation of ion transmembrane transport|
|negative regulation of cell morphogenesis involved in differentiation|
|inner ear morphogenesis|
|dendrite development|
|positive regulation of ion transmembrane transporter activity|
|regulation of synapse assembly|
|positive regulation of transporter activity|
|camera-type eye morphogenesis|
|regulation of protein localization to cell periphery|
|negative regulation of transmembrane transport|
|ear morphogenesis|
|positive regulation of protein localization to membrane|
|positive regulation of cation transmembrane transport|
|peptidyl-tyrosine phosphorylation|
|learning|
|negative regulation of ion transport|
|peptidyl-tyrosine modification|
|eye morphogenesis|
|positive regulation of synaptic transmission|
|negative regulation of neuron projection development|
|positive regulation of ion transmembrane transport|
|negative regulation of MAPK cascade|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|central nervous system neuron differentiation|
|negative regulation of cell projection organization|
|regulation of axonogenesis|
|regulation of synaptic plasticity|
|regulation of protein localization to membrane|
|inner ear development|
|positive regulation of transmembrane transport|
|receptor complex|
|regulation of synapse organization|
|ear development|
|negative regulation of protein kinase activity|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|cell recognition|
|regulation of Ras protein signal transduction|
|negative regulation of kinase activity|
|sensory organ morphogenesis|
|telencephalon development|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|axon guidance|
|neuron projection guidance|
|regulation of transmembrane transporter activity|
|protein-containing complex binding|
|synapse organization|
|positive regulation of ion transport|
|negative regulation of transferase activity|
|regulation of transporter activity|
|embryonic organ morphogenesis|
|negative regulation of neurogenesis|
|regulation of ERK1 and ERK2 cascade|
|axon|
|cognition|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|camera-type eye development|
|angiogenesis|
|urogenital system development|
|neuron projection|
|positive regulation of cellular protein localization|
|regulation of cation transmembrane transport|
|negative regulation of cell development|
|signaling receptor binding|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|glutamatergic synapse|
|eye development|
|visual system development|
|sensory system development|
|neuronal cell body|
|axonogenesis|
|forebrain development|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|axon development|
|dendrite|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of phosphorylation|
|synaptic signaling|
|positive regulation of neurogenesis|
|regulation of ion transmembrane transport|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|negative regulation of transport|
|blood vessel development|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of body fluid levels|
|negative regulation of intracellular signal transduction|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|sensory organ development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|embryonic morphogenesis|
|behavior|
|negative regulation of protein modification process|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|brain development|
|regulation of MAPK cascade|
|head development|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|membrane organization|
|circulatory system development|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|regulation of transferase activity|
|central nervous system development|
|positive regulation of transport|
|neuron differentiation|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|phosphorylation|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|ATP binding|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|extracellular region|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10145
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPHB2 Expression in NALM6 Cells: 0.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>