EPPK1 [The Human Chemical-Genetic Interaction Map Project]

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======= EPPK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPPK1
  * **<color #00a2e8>Official Name</color>**: epiplakin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83481|83481]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P58107|P58107]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPPK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPPK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607553|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the plakin family of proteins, which play a role in the organization of cytoskeletal architecture. This family member is composed of several highly homologous plakin repeats. It may function to maintain the integrity of keratin intermediate filament networks in epithelial cells. Studies of the orthologous mouse protein suggest that it accelerates keratinocyte migration during wound healing. [provided by RefSeq, Oct 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed:15671067, PubMed:27206504, PubMed:23398049). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed:27206504, PubMed:23398049). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization (By similarity). {ECO:0000250|UniProtKB:Q8R0W0, ECO:0000269|PubMed:15671067, ECO:0000269|PubMed:23398049, ECO:0000269|PubMed:27206504}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Plectin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|perinucleolar compartment|
|negative regulation of keratinocyte migration|
|regulation of epithelium regeneration|
|keratin filament binding|
|intermediate filament bundle assembly|
|hemidesmosome|
|intermediate filament binding|
|negative regulation of keratinocyte proliferation|
|regulation of keratinocyte migration|
|apicolateral plasma membrane|
|intermediate filament organization|
|regulation of keratinocyte proliferation|
|cell periphery|
|intermediate filament cytoskeleton organization|
|intermediate filament-based process|
|negative regulation of epithelial cell migration|
|negative regulation of wound healing|
|negative regulation of response to wounding|
|cell projection|
|keratin filament|
|intermediate filament|
|bicellular tight junction|
|negative regulation of epithelial cell proliferation|
|regulation of wound healing|
|regulation of response to wounding|
|structural molecule activity|
|basolateral plasma membrane|
|regulation of epithelial cell migration|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regulation of developmental growth|
|regulation of epithelial cell proliferation|
|negative regulation of response to external stimulus|
|cytoskeleton|
|supramolecular fiber organization|
|wound healing|
|response to wounding|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of cell migration|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of response to external stimulus|
|cytoskeleton organization|
|negative regulation of multicellular organismal process|
|RNA binding|
|regulation of response to stress|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp433|LJH685 50μM R08 exp433]]|-1.92|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.71|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4379
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPPK1 Expression in NALM6 Cells: -0.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>