ERBB2 [The Human Chemical-Genetic Interaction Map Project]

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======= ERBB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ERBB2
  * **<color #00a2e8>Official Name</color>**: erb-b2 receptor tyrosine kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2064|2064]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04626|P04626]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ERBB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ERBB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164870|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|Recep L domain|
|Furin-like|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of immature T cell proliferation in thymus|
|ErbB-3 class receptor binding|
|negative regulation of immature T cell proliferation|
|regulation of immature T cell proliferation in thymus|
|RNA polymerase I core binding|
|regulation of immature T cell proliferation|
|negative regulation of T cell differentiation in thymus|
|positive regulation of transcription by RNA polymerase I|
|regulation of T cell differentiation in thymus|
|motor neuron axon guidance|
|myelin sheath|
|positive regulation of protein targeting to membrane|
|ERBB2 signaling pathway|
|regulation of transcription by RNA polymerase I|
|growth factor binding|
|phosphatidylinositol 3-kinase signaling|
|basal plasma membrane|
|regulation of protein targeting to membrane|
|neuromuscular junction development|
|cellular response to epidermal growth factor stimulus|
|negative regulation of T cell differentiation|
|response to epidermal growth factor|
|negative regulation of ERBB signaling pathway|
|negative regulation of lymphocyte differentiation|
|transmembrane receptor protein tyrosine kinase activity|
|negative regulation of T cell proliferation|
|oligodendrocyte differentiation|
|ERBB signaling pathway|
|phosphatidylinositol-mediated signaling|
|peripheral nervous system development|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|inositol lipid-mediated signaling|
|negative regulation of leukocyte proliferation|
|regulation of protein targeting|
|protein phosphatase binding|
|protein tyrosine kinase activity|
|regulation of ERBB signaling pathway|
|negative regulation of leukocyte differentiation|
|myelination|
|axon ensheathment|
|ensheathment of neurons|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|positive regulation of protein localization to membrane|
|positive regulation of translation|
|negative regulation of hemopoiesis|
|transmembrane signaling receptor activity|
|regulation of T cell differentiation|
|peptidyl-tyrosine phosphorylation|
|negative regulation of lymphocyte activation|
|peptidyl-tyrosine modification|
|positive regulation of cellular amide metabolic process|
|positive regulation of intracellular protein transport|
|regulation of T cell proliferation|
|protein dimerization activity|
|positive regulation of cell growth|
|positive regulation of protein kinase B signaling|
|regulation of lymphocyte differentiation|
|glial cell differentiation|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|regulation of protein localization to membrane|
|protein C-terminus binding|
|positive regulation of epithelial cell proliferation|
|protein autophosphorylation|
|negative regulation of cell activation|
|basolateral plasma membrane|
|receptor complex|
|positive regulation of intracellular transport|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|endosome membrane|
|gliogenesis|
|regulation of protein kinase B signaling|
|regulation of leukocyte proliferation|
|regulation of microtubule-based process|
|regulation of intracellular protein transport|
|positive regulation of growth|
|axon guidance|
|neuron projection guidance|
|positive regulation of MAP kinase activity|
|synapse organization|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|regulation of angiogenesis|
|regulation of ERK1 and ERK2 cascade|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|apical plasma membrane|
|regulation of vasculature development|
|positive regulation of cellular protein localization|
|regulation of epithelial cell proliferation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of intracellular transport|
|regulation of translation|
|MAPK cascade|
|axonogenesis|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|regulation of cellular amide metabolic process|
|axon development|
|positive regulation of GTPase activity|
|regulation of cell growth|
|positive regulation of protein transport|
|cell morphogenesis involved in neuron differentiation|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|positive regulation of establishment of protein localization|
|wound healing|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|protein heterodimerization activity|
|cell projection morphogenesis|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|posttranscriptional regulation of gene expression|
|heart development|
|response to growth factor|
|positive regulation of protein kinase activity|
|regulation of cellular protein localization|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|response to wounding|
|positive regulation of kinase activity|
|regulation of leukocyte activation|
|regulation of cell activation|
|positive regulation of transferase activity|
|neuron projection development|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|neuron development|
|cellular component morphogenesis|
|circulatory system development|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|protein phosphorylation|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 17/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|4/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8127
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ERBB2 Expression in NALM6 Cells: 3.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>