ERBB3 [The Human Chemical-Genetic Interaction Map Project]

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======= ERBB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ERBB3
  * **<color #00a2e8>Official Name</color>**: erb-b2 receptor tyrosine kinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2065|2065]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21860|P21860]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ERBB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ERBB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190151|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
|Furin-like|
|Recep L domain|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuregulin receptor activity|
|neuregulin binding|
|protein tyrosine kinase activator activity|
|positive regulation of calcineurin-mediated signaling|
|positive regulation of calcineurin-NFAT signaling cascade|
|signal transduction in absence of ligand|
|extrinsic apoptotic signaling pathway in absence of ligand|
|ERBB2 signaling pathway|
|growth factor binding|
|phosphatidylinositol 3-kinase signaling|
|basal plasma membrane|
|regulation of calcineurin-mediated signaling|
|regulation of calcineurin-NFAT signaling cascade|
|Schwann cell differentiation|
|endocardial cushion development|
|positive regulation of calcium-mediated signaling|
|neuron apoptotic process|
|positive regulation of cardiac muscle tissue development|
|cranial nerve development|
|neuron death|
|positive regulation of protein tyrosine kinase activity|
|transmembrane receptor protein tyrosine kinase activity|
|lateral plasma membrane|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|ERBB signaling pathway|
|positive regulation of muscle tissue development|
|phosphatidylinositol-mediated signaling|
|peripheral nervous system development|
|inositol lipid-mediated signaling|
|nerve development|
|regulation of cardiac muscle tissue development|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|protein tyrosine kinase activity|
|regulation of protein tyrosine kinase activity|
|regulation of calcium-mediated signaling|
|extrinsic apoptotic signaling pathway|
|regulation of phosphatidylinositol 3-kinase signaling|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|transmembrane signaling receptor activity|
|peptidyl-tyrosine phosphorylation|
|negative regulation of neuron apoptotic process|
|peptidyl-tyrosine modification|
|positive regulation of protein kinase B signaling|
|glial cell differentiation|
|positive regulation of peptidyl-tyrosine phosphorylation|
|basolateral plasma membrane|
|receptor complex|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|gliogenesis|
|regulation of protein kinase B signaling|
|mesenchyme development|
|negative regulation of secretion|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of cell adhesion|
|apoptotic signaling pathway|
|ubiquitin protein ligase binding|
|regulation of neuron death|
|apical plasma membrane|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|wound healing|
|negative regulation of transport|
|protein heterodimerization activity|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|heart development|
|positive regulation of protein kinase activity|
|response to wounding|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|regulation of cell adhesion|
|enzyme linked receptor protein signaling pathway|
|regulation of protein kinase activity|
|regulation of secretion|
|circulatory system development|
|regulation of kinase activity|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|apoptotic process|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|positive regulation of phosphorylation|
|identical protein binding|
|cell death|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|4/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13912
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ERBB3 Expression in NALM6 Cells: 2.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>