ERG [The Human Chemical-Genetic Interaction Map Project]

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======= ERG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ERG
  * **<color #00a2e8>Official Name</color>**: ETS transcription factor ERG
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2078|2078]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11308|P11308]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ERG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ERG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/165080|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ets|
|SAM PNT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribonucleoprotein complex|
|chromatin binding|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|protein phosphorylation|
|positive regulation of transcription by RNA polymerase II|
|phosphorylation|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.4|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.31|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.3|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.16|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.14|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-2.06|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-2.06|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.97|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.91|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.91|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.91|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.91|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.89|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.88|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.85|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.84|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.8|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.77|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.75|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.73|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.71|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.7|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.74|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.91|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.93|
|[[:results:exp148|SB202190 10μM R03 exp148]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lmo2|LMO2]]|0.614|
|[[:human genes:l:ldb1|LDB1]]|0.559|
|[[:human genes:z:znf319|ZNF319]]|0.544|
|[[:human genes:f:fli1|FLI1]]|0.526|
|[[:human genes:x:xpo6|XPO6]]|0.492|
|[[:human genes:s:scaf8|SCAF8]]|0.486|
|[[:human genes:l:lyl1|LYL1]]|0.456|
|[[:human genes:s:ssbp2|SSBP2]]|0.445|
|[[:human genes:n:nsd1|NSD1]]|0.439|
|[[:human genes:p:pias4|PIAS4]]|0.437|
|[[:human genes:s:setd1b|SETD1B]]|0.435|
|[[:human genes:b:brpf1|BRPF1]]|0.432|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.431|
|[[:human genes:s:sox7|SOX7]]|0.42|
|[[:human genes:c:ccdc101|CCDC101]]|0.415|
|[[:human genes:s:shoc2|SHOC2]]|0.409|
|[[:human genes:m:mef2c|MEF2C]]|0.409|
|[[:human genes:i:id3|ID3]]|0.408|
|[[:human genes:t:tada3|TADA3]]|0.403|
|[[:human genes:t:tle4|TLE4]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1823
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ERG Expression in NALM6 Cells: 6.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>