ERGIC1 [The Human Chemical-Genetic Interaction Map Project]

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======= ERGIC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ERGIC1
  * **<color #00a2e8>Official Name</color>**: endoplasmic reticulum-golgi intermediate compartment 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57222|57222]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969X5|Q969X5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ERGIC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ERGIC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617946|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Possible role in transport between endoplasmic reticulum and Golgi. {ECO:0000303|PubMed:15308636}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COPIIcoated ERV|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|endoplasmic reticulum-Golgi intermediate compartment|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|Golgi vesicle transport|
|Golgi membrane|
|intracellular membrane-bounded organelle|
|endoplasmic reticulum membrane|
|intracellular transport|
|establishment of localization in cell|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.6|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.82|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.73|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.73|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.83|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.87|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.97|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.98|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.05|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.1|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.28|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.52|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.56|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.7|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|4.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:igll1|IGLL1]]|0.704|
|[[:human genes:s:syk|SYK]]|0.662|
|[[:human genes:r:rhoh|RHOH]]|0.655|
|[[:human genes:c:cd79a|CD79A]]|0.644|
|[[:human genes:c:cd79b|CD79B]]|0.615|
|[[:human genes:p:pik3cd|PIK3CD]]|0.593|
|[[:human genes:c:cd19|CD19]]|0.538|
|[[:human genes:c:cd81|CD81]]|0.477|
|[[:human genes:s:ssr3|SSR3]]|0.438|
|[[:human genes:a:akt2|AKT2]]|0.431|
|[[:human genes:n:nras|NRAS]]|0.417|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.413|
|[[:human genes:g:gna15|GNA15]]|0.41|
|[[:human genes:m:mmd|MMD]]|0.406|
|[[:human genes:i:itpr1|ITPR1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2585
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ERGIC1 Expression in NALM6 Cells: 8.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>