ERO1L [The Human Chemical-Genetic Interaction Map Project]

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======= ERO1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ERO1A
  * **<color #00a2e8>Official Name</color>**: endoplasmic reticulum oxidoreductase 1 alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=30001|30001]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96HE7|Q96HE7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ERO1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ERO1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615435|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:10970843, ECO:0000269|PubMed:11707400, ECO:0000269|PubMed:12403808, ECO:0000269|PubMed:18833192, ECO:0000269|PubMed:18971943, ECO:0000269|PubMed:23027870}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ERO1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|animal organ senescence|
|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|
|protein maturation by protein folding|
|4-hydroxyproline metabolic process|
|protein folding in endoplasmic reticulum|
|protein disulfide isomerase activity|
|protein disulfide oxidoreductase activity|
|brown fat cell differentiation|
|chaperone cofactor-dependent protein refolding|
|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|
|de novo posttranslational protein folding|
|de novo protein folding|
|release of sequestered calcium ion into cytosol|
|negative regulation of sequestering of calcium ion|
|chaperone-mediated protein folding|
|calcium ion transmembrane import into cytosol|
|calcium ion transport into cytosol|
|cell redox homeostasis|
|cytosolic calcium ion transport|
|endoplasmic reticulum unfolded protein response|
|fat cell differentiation|
|oxidoreductase activity|
|regulation of sequestering of calcium ion|
|cellular response to unfolded protein|
|cellular response to topologically incorrect protein|
|intrinsic apoptotic signaling pathway|
|response to unfolded protein|
|response to temperature stimulus|
|response to topologically incorrect protein|
|cellular response to hypoxia|
|calcium ion transmembrane transport|
|cellular modified amino acid metabolic process|
|cellular response to decreased oxygen levels|
|alpha-amino acid metabolic process|
|cellular response to oxygen levels|
|protein maturation|
|protein folding|
|cellular response to oxidative stress|
|calcium ion transport|
|response to endoplasmic reticulum stress|
|aging|
|positive regulation of cytosolic calcium ion concentration|
|apoptotic signaling pathway|
|divalent metal ion transport|
|divalent inorganic cation transport|
|endoplasmic reticulum lumen|
|cellular amino acid metabolic process|
|regulation of cytosolic calcium ion concentration|
|extracellular matrix organization|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|extracellular structure organization|
|response to oxidative stress|
|dendrite|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|intracellular membrane-bounded organelle|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|carboxylic acid metabolic process|
|apoptotic process|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|oxidation-reduction process|
|oxoacid metabolic process|
|endoplasmic reticulum|
|organic acid metabolic process|
|programmed cell death|
|cell death|
|chemical homeostasis|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|homeostatic process|
|intracellular signal transduction|
|cellular response to stress|
|small molecule metabolic process|
|establishment of localization in cell|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp302|35°C R06 exp302]]|-1.71|
|[[:results:exp483|FTY720 3μM R08 exp483]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14732
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ERO1L Expression in NALM6 Cells: 6.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>