ESCO2 [The Human Chemical-Genetic Interaction Map Project]

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======= ESCO2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ESCO2
  * **<color #00a2e8>Official Name</color>**: establishment of sister chromatid cohesion N-acetyltransferase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=157570|157570]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q56NI9|Q56NI9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ESCO2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ESCO2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609353|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that may have acetyltransferase activity and may be required for the establishment of sister chromatid cohesion during the S phase of mitosis. Mutations in this gene have been associated with Roberts syndrome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3. {ECO:0000269|PubMed:15821733, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|post-translational protein acetylation|
|lysine N-acetyltransferase activity, acting on acetyl phosphate as donor|
|nuclear pericentric heterochromatin|
|chromocenter|
|XY body|
|acetyltransferase activity|
|protein localization to chromatin|
|sister chromatid cohesion|
|site of double-strand break|
|protein localization to chromosome|
|hematopoietic progenitor cell differentiation|
|regulation of DNA replication|
|chromatin|
|chromosome|
|sister chromatid segregation|
|protein acetylation|
|double-strand break repair|
|protein acylation|
|nuclear chromosome segregation|
|chromosome segregation|
|post-translational protein modification|
|DNA repair|
|cell junction|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|protein localization to organelle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|Golgi apparatus|
|cell cycle process|
|chromosome organization|
|cell cycle|
|cellular protein localization|
|cellular macromolecule localization|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-3.22|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.8|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.67|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.63|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.62|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.46|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.42|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.34|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.26|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.24|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-2.01|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.92|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.8|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.76|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.75|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.74|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.75|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.84|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.87|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.98|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.57|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tacc3|TACC3]]|0.487|
|[[:human genes:g:gsg2|GSG2]]|0.447|
|[[:human genes:c:cdca2|CDCA2]]|0.441|
|[[:human genes:c:ccnb1|CCNB1]]|0.43|
|[[:human genes:d:dlgap5|DLGAP5]]|0.429|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4866
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ESCO2 Expression in NALM6 Cells: 6.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>