EVL [The Human Chemical-Genetic Interaction Map Project]

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======= EVL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EVL
  * **<color #00a2e8>Official Name</color>**: Enah/Vasp-like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51466|51466]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UI08|Q9UI08]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EVL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EVL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616912|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WH1|
|VASP tetra|
|VASP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of ruffle assembly|
|profilin binding|
|negative regulation of plasma membrane bounded cell projection assembly|
|regulation of ruffle assembly|
|actin nucleation|
|actin polymerization or depolymerization|
|positive regulation of stress fiber assembly|
|phagocytic vesicle|
|positive regulation of actin filament bundle assembly|
|negative regulation of epithelial cell migration|
|regulation of stress fiber assembly|
|regulation of actomyosin structure organization|
|positive regulation of actin filament polymerization|
|regulation of actin filament bundle assembly|
|protein homotetramerization|
|positive regulation of protein polymerization|
|SH3 domain binding|
|protein tetramerization|
|cellular response to interferon-gamma|
|regulation of actin filament polymerization|
|lamellipodium|
|response to interferon-gamma|
|negative regulation of cell projection organization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of epithelial cell migration|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|actin filament organization|
|positive regulation of protein complex assembly|
|negative regulation of cell migration|
|axon guidance|
|regulation of actin filament organization|
|neuron projection guidance|
|actin binding|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|protein homooligomerization|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|cytoskeleton|
|axonogenesis|
|regulation of cellular component size|
|regulation of actin filament-based process|
|axon development|
|focal adhesion|
|cell morphogenesis involved in neuron differentiation|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|cell part morphogenesis|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|actin filament-based process|
|positive regulation of organelle organization|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|cell morphogenesis|
|innate immune response|
|neuron development|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of cell motility|
|defense response to other organism|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|neuron differentiation|
|response to cytokine|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|generation of neurons|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|neurogenesis|
|cell development|
|protein-containing complex subunit organization|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4531
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EVL Expression in NALM6 Cells: 6.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>