EXO1 [The Human Chemical-Genetic Interaction Map Project]

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======= EXO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EXO1
  * **<color #00a2e8>Official Name</color>**: exonuclease 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9156|9156]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UQ84|Q9UQ84]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EXO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EXO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606063|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch- containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837, ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105, ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184, ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|XPG N|
|XPG I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|double-stranded DNA 5-3 exodeoxyribonuclease activity|
|single-stranded DNA 5-3 exodeoxyribonuclease activity|
|flap endonuclease activity|
|5-3 exodeoxyribonuclease activity|
|5-flap endonuclease activity|
|telomere maintenance via telomere trimming|
|5-3 exonuclease activity|
|formation of extrachromosomal circular DNA|
|t-circle formation|
|exonuclease activity|
|RNA-DNA hybrid ribonuclease activity|
|somatic hypermutation of immunoglobulin genes|
|somatic recombination of immunoglobulin genes involved in immune response|
|isotype switching|
|somatic diversification of immunoglobulins involved in immune response|
|somatic diversification of immune receptors via somatic mutation|
|somatic recombination of immunoglobulin gene segments|
|immunoglobulin production involved in immunoglobulin mediated immune response|
|mismatch repair|
|somatic diversification of immunoglobulins|
|somatic cell DNA recombination|
|somatic diversification of immune receptors via germline recombination within a single locus|
|B cell activation involved in immune response|
|somatic diversification of immune receptors|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|telomere maintenance|
|telomere organization|
|lymphocyte activation involved in immune response|
|B cell activation|
|immunoglobulin production|
|RNA phosphodiester bond hydrolysis|
|humoral immune response mediated by circulating immunoglobulin|
|production of molecular mediator of immune response|
|regulation of signal transduction by p53 class mediator|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|DNA replication|
|DNA recombination|
|meiotic cell cycle|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|nuclear body|
|nucleic acid phosphodiester bond hydrolysis|
|anatomical structure homeostasis|
|humoral immune response|
|lymphocyte activation|
|chromatin binding|
|DNA repair|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|DNA metabolic process|
|leukocyte mediated immunity|
|cellular response to DNA damage stimulus|
|leukocyte activation|
|chromosome organization|
|cell activation|
|immune effector process|
|cell cycle|
|reproductive process|
|reproduction|
|DNA binding|
|homeostatic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.74|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.79|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.89|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12376
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EXO1 Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>