EXOC3 [The Human Chemical-Genetic Interaction Map Project]

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======= EXOC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EXOC3
  * **<color #00a2e8>Official Name</color>**: exocyst complex component 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11336|11336]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60645|O60645]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EXOC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EXOC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608186|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|exocyst localization|
|exocyst|
|cellular protein-containing complex localization|
|SNARE binding|
|presynaptic membrane|
|secretory granule membrane|
|growth cone|
|midbody|
|protein-containing complex localization|
|cadherin binding|
|perinuclear region of cytoplasm|
|exocytosis|
|Golgi apparatus|
|secretion by cell|
|export from cell|
|secretion|
|protein transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.89|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.76|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.73|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.558|
|[[:human genes:r:rnmt|RNMT]]|0.538|
|[[:human genes:p:pelo|PELO]]|0.53|
|[[:human genes:e:exoc4|EXOC4]]|0.526|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.517|
|[[:human genes:g:gmppb|GMPPB]]|0.512|
|[[:human genes:r:rpp21|RPP21]]|0.508|
|[[:human genes:v:vezt|VEZT]]|0.506|
|[[:human genes:d:ddx20|DDX20]]|0.5|
|[[:human genes:h:hars|HARS]]|0.495|
|[[:human genes:p:pmm2|PMM2]]|0.485|
|[[:human genes:a:alg1|ALG1]]|0.484|
|[[:human genes:e:eprs|EPRS]]|0.483|
|[[:human genes:s:srp14|SRP14]]|0.483|
|[[:human genes:d:ddost|DDOST]]|0.48|
|[[:human genes:d:dhps|DHPS]]|0.472|
|[[:human genes:t:triap1|TRIAP1]]|0.467|
|[[:human genes:r:rpn1|RPN1]]|0.463|
|[[:human genes:n:nsmce1|NSMCE1]]|0.463|
|[[:human genes:n:nae1|NAE1]]|0.462|
|[[:human genes:r:rtcb|RTCB]]|0.461|
|[[:human genes:a:adsl|ADSL]]|0.461|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.461|
|[[:human genes:g:gfpt1|GFPT1]]|0.459|
|[[:human genes:r:rptor|RPTOR]]|0.458|
|[[:human genes:g:gemin5|GEMIN5]]|0.453|
|[[:human genes:m:med16|MED16]]|0.452|
|[[:human genes:e:exoc5|EXOC5]]|0.449|
|[[:human genes:p:polr3h|POLR3H]]|0.447|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.447|
|[[:human genes:u:utp23|UTP23]]|0.446|
|[[:human genes:g:gemin8|GEMIN8]]|0.445|
|[[:human genes:d:dohh|DOHH]]|0.442|
|[[:human genes:h:hspd1|HSPD1]]|0.44|
|[[:human genes:d:dpagt1|DPAGT1]]|0.434|
|[[:human genes:a:atxn10|ATXN10]]|0.432|
|[[:human genes:d:dad1|DAD1]]|0.429|
|[[:human genes:g:gemin7|GEMIN7]]|0.429|
|[[:human genes:r:rabggtb|RABGGTB]]|0.424|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.423|
|[[:human genes:c:ccdc115|CCDC115]]|0.418|
|[[:human genes:u:uap1|UAP1]]|0.417|
|[[:human genes:g:gnb1l|GNB1L]]|0.417|
|[[:human genes:y:yars|YARS]]|0.416|
|[[:human genes:t:txnl4b|TXNL4B]]|0.416|
|[[:human genes:o:osgep|OSGEP]]|0.416|
|[[:human genes:e:eno1|ENO1]]|0.412|
|[[:human genes:d:dicer1|DICER1]]|0.411|
|[[:human genes:s:snapc5|SNAPC5]]|0.411|
|[[:human genes:g:gemin6|GEMIN6]]|0.41|
|[[:human genes:t:tti2|TTI2]]|0.41|
|[[:human genes:o:oip5|OIP5]]|0.41|
|[[:human genes:t:tsen54|TSEN54]]|0.41|
|[[:human genes:w:wdr82|WDR82]]|0.408|
|[[:human genes:p:pam16|PAM16]]|0.407|
|[[:human genes:r:rpe|RPE]]|0.407|
|[[:human genes:f:faf2|FAF2]]|0.404|
|[[:human genes:l:lsm11|LSM11]]|0.403|
|[[:human genes:t:tbca|TBCA]]|0.403|
|[[:human genes:t:tti1|TTI1]]|0.403|
|[[:human genes:m:mtor|MTOR]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 46/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|2/20|
|lung|11/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|4/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 840
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EXOC3 Expression in NALM6 Cells: 5.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>