F2RL1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= F2RL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: F2RL1
  * **<color #00a2e8>Official Name</color>**: F2R like trypsin receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2150|2150]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55085|P55085]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=F2RL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20F2RL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600933|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho (PubMed:28445455). Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (PubMed:23202369). Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E- cadherin adhesion (PubMed:10086357). Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders. {ECO:0000269|PubMed:10086357, ECO:0000269|PubMed:10725339, ECO:0000269|PubMed:11413129, ECO:0000269|PubMed:11441110, ECO:0000269|PubMed:11447194, ECO:0000269|PubMed:11714832, ECO:0000269|PubMed:12832443, ECO:0000269|PubMed:15155775, ECO:0000269|PubMed:16359518, ECO:0000269|PubMed:16410250, ECO:0000269|PubMed:16478888, ECO:0000269|PubMed:16714334, ECO:0000269|PubMed:17404307, ECO:0000269|PubMed:17500066, ECO:0000269|PubMed:18424071, ECO:0000269|PubMed:18453611, ECO:0000269|PubMed:18474671, ECO:0000269|PubMed:18622013, ECO:0000269|PubMed:19494303, ECO:0000269|PubMed:19781631, ECO:0000269|PubMed:19864598, ECO:0000269|PubMed:19865078, ECO:0000269|PubMed:20826780, ECO:0000269|PubMed:21501162, ECO:0000269|PubMed:23202369, ECO:0000269|PubMed:28445455}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srw|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of neutrophil mediated killing of gram-negative bacterium|
|positive regulation of neutrophil mediated killing of bacterium|
|negative regulation of chemokine secretion|
|regulation of neutrophil mediated killing of bacterium|
|interleukin-10 secretion|
|positive regulation of neutrophil mediated killing of symbiont cell|
|positive regulation of eosinophil activation|
|positive regulation of neutrophil mediated cytotoxicity|
|regulation of neutrophil mediated killing of gram-negative bacterium|
|positive regulation of renin secretion into blood stream|
|positive regulation of eosinophil degranulation|
|regulation of neutrophil mediated killing of symbiont cell|
|negative regulation of toll-like receptor 3 signaling pathway|
|chemokine (C-C motif) ligand 2 secretion|
|regulation of eosinophil degranulation|
|chemokine (C-X-C motif) ligand 2 production|
|chemokine secretion|
|regulation of eosinophil activation|
|regulation of renin secretion into blood stream|
|positive regulation of glomerular filtration|
|interleukin-10 production|
|mature conventional dendritic cell differentiation|
|thrombin-activated receptor activity|
|regulation of neutrophil mediated cytotoxicity|
|positive regulation of toll-like receptor 2 signaling pathway|
|positive regulation of toll-like receptor 3 signaling pathway|
|positive regulation of cytokine secretion involved in immune response|
|thrombin-activated receptor signaling pathway|
|positive regulation of toll-like receptor 4 signaling pathway|
|chemokine production|
|interferon-gamma secretion|
|interleukin-1 beta secretion|
|regulation of toll-like receptor 3 signaling pathway|
|positive regulation of defense response to bacterium|
|regulation of toll-like receptor 2 signaling pathway|
|interleukin-1 secretion|
|regulation of glomerular filtration|
|cell-cell junction maintenance|
|positive regulation of pseudopodium assembly|
|positive regulation of membrane invagination|
|positive regulation of phagocytosis, engulfment|
|positive regulation of actin filament depolymerization|
|positive regulation of killing of cells of other organism|
|regulation of pseudopodium assembly|
|interleukin-1 beta production|
|cell junction maintenance|
|positive regulation of interleukin-8 secretion|
|regulation of phagocytosis, engulfment|
|regulation of chemokine secretion|
|interleukin-1 production|
|renal system process involved in regulation of blood volume|
|regulation of membrane invagination|
|regulation of cytokine secretion involved in immune response|
|regulation of killing of cells of other organism|
|pseudopodium|
|regulation of defense response to bacterium|
|positive regulation of superoxide anion generation|
|interferon-gamma production|
|negative regulation of chemokine production|
|G-protein beta-subunit binding|
|positive regulation of protein depolymerization|
|regulation of toll-like receptor 4 signaling pathway|
|negative regulation of tumor necrosis factor-mediated signaling pathway|
|regulation of superoxide anion generation|
|positive regulation of toll-like receptor signaling pathway|
|positive regulation of leukocyte degranulation|
|regulation of interleukin-8 secretion|
|G-protein alpha-subunit binding|
|renal system process involved in regulation of systemic arterial blood pressure|
|positive regulation of positive chemotaxis|
|regulation of positive chemotaxis|
|positive regulation of Rho protein signal transduction|
|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|
|positive regulation of myeloid leukocyte mediated immunity|
|positive regulation of interleukin-6 secretion|
|dendritic cell differentiation|
|establishment of endothelial barrier|
|regulation of superoxide metabolic process|
|regulation of renal system process|
|negative regulation of JNK cascade|
|positive regulation of protein complex disassembly|
|negative regulation of toll-like receptor signaling pathway|
|regulation of endocrine process|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of stress-activated protein kinase signaling cascade|
|cellular component maintenance|
|cytokine secretion|
|positive regulation of interleukin-8 production|
|regulation of leukocyte degranulation|
|endothelial cell development|
|regulation of actin filament depolymerization|
|positive regulation of regulated secretory pathway|
|positive regulation of cytokine production involved in immune response|
|positive regulation of leukocyte mediated cytotoxicity|
|positive regulation of blood vessel diameter|
|regulation of tumor necrosis factor-mediated signaling pathway|
|regulation of myeloid leukocyte mediated immunity|
|negative regulation of cytokine-mediated signaling pathway|
|T cell activation involved in immune response|
|positive regulation of Ras protein signal transduction|
|negative regulation of response to cytokine stimulus|
|positive regulation of cell killing|
|regulation of toll-like receptor signaling pathway|
|negative regulation of cytokine secretion|
|positive regulation of phagocytosis|
|regulation of interleukin-8 production|
|positive regulation of blood circulation|
|positive regulation of small GTPase mediated signal transduction|
|regulation of leukocyte mediated cytotoxicity|
|regulation of chemokine production|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|endothelial cell differentiation|
|regulation of protein depolymerization|
|regulation of cytokine production involved in immune response|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of leukocyte chemotaxis|
|positive regulation of exocytosis|
|regulation of systemic arterial blood pressure|
|positive regulation of interleukin-6 production|
|positive regulation of reactive oxygen species metabolic process|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|endothelium development|
|regulation of phagocytosis|
|positive regulation of production of molecular mediator of immune response|
|leukocyte proliferation|
|positive regulation of endocytosis|
|regulation of cell killing|
|positive regulation of plasma membrane bounded cell projection assembly|
|renal system process|
|lymphocyte activation involved in immune response|
|myeloid leukocyte differentiation|
|regulation of leukocyte chemotaxis|
|regulation of protein complex disassembly|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of leukocyte migration|
|negative regulation of protein secretion|
|positive regulation of leukocyte mediated immunity|
|positive regulation of chemotaxis|
|regulation of wound healing|
|cell-cell junction organization|
|regulation of blood vessel diameter|
|positive regulation of JNK cascade|
|regulation of tube diameter|
|negative regulation of peptide secretion|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|regulation of tube size|
|regulation of production of molecular mediator of immune response|
|regulation of Rho protein signal transduction|
|cytokine production|
|protein secretion|
|establishment of protein localization to extracellular region|
|regulation of cytokine-mediated signaling pathway|
|regulation of regulated secretory pathway|
|protein localization to extracellular region|
|positive regulation of stress-activated MAPK cascade|
|regulation of response to wounding|
|negative regulation of MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|vascular process in circulatory system|
|peptide secretion|
|regulation of response to cytokine stimulus|
|regulation of reactive oxygen species metabolic process|
|regulation of blood pressure|
|negative regulation of protein transport|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of JNK cascade|
|negative regulation of establishment of protein localization|
|defense response to virus|
|epithelial cell development|
|regulation of leukocyte migration|
|positive regulation of supramolecular fiber organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|signaling receptor activity|
|regulation of endocytosis|
|regulation of leukocyte mediated immunity|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|cell junction organization|
|positive regulation of immune effector process|
|myeloid cell differentiation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|positive regulation of cytoskeleton organization|
|regulation of exocytosis|
|negative regulation of secretion|
|regulation of stress-activated MAPK cascade|
|T cell activation|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|regulation of Ras protein signal transduction|
|early endosome|
|regulation of actin filament organization|
|positive regulation of protein secretion|
|negative regulation of cytokine production|
|response to virus|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|positive regulation of peptide secretion|
|blood coagulation|
|regulation of ERK1 and ERK2 cascade|
|coagulation|
|hemostasis|
|regulation of cytosolic calcium ion concentration|
|leukocyte differentiation|
|signaling receptor binding|
|positive regulation of innate immune response|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|positive regulation of response to biotic stimulus|
|regulation of cellular component size|
|leukocyte migration|
|positive regulation of cell projection organization|
|lymphocyte activation|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|negative regulation of protein phosphorylation|
|positive regulation of GTPase activity|
|positive regulation of cell activation|
|positive regulation of protein transport|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|positive regulation of cytokine production|
|calcium ion homeostasis|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|cellular divalent inorganic cation homeostasis|
|positive regulation of defense response|
|wound healing|
|regulation of GTPase activity|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of body fluid levels|
|inflammatory response|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|negative regulation of intracellular signal transduction|
|positive regulation of multi-organism process|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of response to biotic stimulus|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cell population proliferation|
|hemopoiesis|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|response to wounding|
|myeloid leukocyte activation|
|regulation of system process|
|negative regulation of protein modification process|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|positive regulation of organelle organization|
|metal ion homeostasis|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular cation homeostasis|
|regulation of cell activation|
|cellular ion homeostasis|
|immune system development|
|epithelial cell differentiation|
|regulation of cytokine production|
|regulation of plasma membrane bounded cell projection organization|
|regulation of protein transport|
|cation homeostasis|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|regulation of cellular response to stress|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|ion homeostasis|
|regulation of secretion|
|regulation of cell migration|
|positive regulation of immune response|
|cellular homeostasis|
|regulation of cell motility|
|leukocyte activation|
|defense response to other organism|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of locomotion|
|Golgi apparatus|
|positive regulation of transport|
|regulation of cellular component movement|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|epithelium development|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|protein transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|amide transport|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.92|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.81|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5209
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='F2RL1 Expression in NALM6 Cells: -0.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>