F7 [The Human Chemical-Genetic Interaction Map Project]

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======= F7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: F7
  * **<color #00a2e8>Official Name</color>**: coagulation factor VII
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2155|2155]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08709|P08709]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=F7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20F7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613878|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Trypsin|
|Gla|
|DUF1986|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to Thyroid stimulating hormone|
|response to carbon dioxide|
|response to astaxanthin|
|response to genistein|
|serine-type peptidase complex|
|response to thyrotropin-releasing hormone|
|response to hydroxyisoflavone|
|response to thyroxine|
|blood coagulation, extrinsic pathway|
|response to L-phenylalanine derivative|
|response to vitamin K|
|response to 2,3,7,8-tetrachlorodibenzodioxine|
|positive regulation of platelet-derived growth factor receptor signaling pathway|
|response to phenylpropanoid|
|response to glycoprotein|
|response to anticoagulant|
|regulation of platelet-derived growth factor receptor signaling pathway|
|positive regulation of positive chemotaxis|
|blood coagulation, fibrin clot formation|
|positive regulation of hemostasis|
|response to thyroid hormone|
|protein activation cascade|
|regulation of positive chemotaxis|
|positive regulation of blood coagulation|
|response to cholesterol|
|positive regulation of coagulation|
|response to sterol|
|response to growth hormone|
|positive regulation of wound healing|
|serine-type peptidase activity|
|positive regulation of response to wounding|
|animal organ regeneration|
|response to estrogen|
|response to anesthetic|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|response to vitamin|
|positive regulation of leukocyte chemotaxis|
|response to antineoplastic agent|
|Golgi lumen|
|regulation of leukocyte chemotaxis|
|response to amino acid|
|positive regulation of leukocyte migration|
|response to estradiol|
|positive regulation of chemotaxis|
|regulation of wound healing|
|vesicle|
|circadian rhythm|
|regeneration|
|protein processing|
|serine-type endopeptidase activity|
|positive regulation of protein kinase B signaling|
|regulation of response to wounding|
|response to ketone|
|regulation of leukocyte migration|
|regulation of chemotaxis|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|response to nutrient|
|regulation of protein kinase B signaling|
|protein maturation|
|response to alcohol|
|rhythmic process|
|blood coagulation|
|coagulation|
|hemostasis|
|response to xenobiotic stimulus|
|endoplasmic reticulum lumen|
|signaling receptor binding|
|response to hypoxia|
|response to acid chemical|
|response to decreased oxygen levels|
|collagen-containing extracellular matrix|
|Golgi vesicle transport|
|response to oxygen levels|
|response to peptide hormone|
|response to peptide|
|wound healing|
|regulation of body fluid levels|
|response to nutrient levels|
|positive regulation of cell migration|
|positive regulation of cell motility|
|response to extracellular stimulus|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|response to wounding|
|positive regulation of response to external stimulus|
|calcium ion binding|
|regulation of cell migration|
|response to lipid|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|response to drug|
|response to nitrogen compound|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|response to abiotic stimulus|
|proteolysis|
|response to endogenous stimulus|
|regulation of response to stress|
|intracellular transport|
|response to oxygen-containing compound|
|extracellular space|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|extracellular region|
|vesicle-mediated transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.15|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.8|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.77|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.7|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.83|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17567
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='F7 Expression in NALM6 Cells: -1.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>