FBXL5 [The Human Chemical-Genetic Interaction Map Project]

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======= FBXL5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FBXL5
  * **<color #00a2e8>Official Name</color>**: F-box and leucine rich repeat protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26234|26234]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKA1|Q9UKA1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FBXL5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FBXL5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605655|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
|F-box|
|F-box-like|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular iron ion homeostasis|
|SCF ubiquitin ligase complex|
|iron ion homeostasis|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|ubiquitin ligase complex|
|cellular transition metal ion homeostasis|
|transition metal ion homeostasis|
|iron ion binding|
|positive regulation of cellular protein catabolic process|
|positive regulation of protein catabolic process|
|ubiquitin-protein transferase activity|
|regulation of cellular protein catabolic process|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|post-translational protein modification|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|positive regulation of catabolic process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|cellular metal ion homeostasis|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|protein catabolic process|
|protein ubiquitination|
|perinuclear region of cytoplasm|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|protein modification by small protein conjugation|
|ion homeostasis|
|regulation of cellular catabolic process|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chemical homeostasis|
|proteolysis|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-3.05|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.98|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.83|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.79|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.76|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.79|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.85|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.87|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.89|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.9|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.97|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.03|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|3.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9270
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FBXL5 Expression in NALM6 Cells: 4.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>