FBXO11 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= FBXO11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FBXO11
  * **<color #00a2e8>Official Name</color>**: F-box protein 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80204|80204]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86XK2|Q86XK2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FBXO11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FBXO11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607871|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-UBR|
|F-box-like|
|F-box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein-arginine N-methyltransferase activity|
|peptidyl-arginine N-methylation|
|peptidyl-arginine methylation|
|peptidyl-arginine modification|
|ubiquitin ligase complex|
|chromosome|
|protein methylation|
|protein alkylation|
|sensory perception of sound|
|sensory perception of mechanical stimulus|
|ubiquitin-protein transferase activity|
|macromolecule methylation|
|protein polyubiquitination|
|methylation|
|post-translational protein modification|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|protein modification by small protein conjugation|
|zinc ion binding|
|nucleolus|
|peptidyl-amino acid modification|
|cellular macromolecule catabolic process|
|sensory perception|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|nervous system process|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|organic substance catabolic process|
|cellular catabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.98|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.8|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.77|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.45|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.35|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-2.29|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-2.17|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-2.12|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.08|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.94|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.93|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.91|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.9|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.89|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.89|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.86|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.74|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.7|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.73|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.75|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.77|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.79|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.81|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.83|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.84|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.86|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.87|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.87|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.93|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.93|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.94|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.95|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.97|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.01|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.08|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.08|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.13|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.15|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.22|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.27|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.37|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.4|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.48|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.49|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.59|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.61|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.62|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.63|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.67|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.68|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.87|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.87|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.88|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.88|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|3.02|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|3.08|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.16|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|3.2|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|3.24|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|3.27|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|3.33|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|3.58|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.67|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|3.87|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.87|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|4.04|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|4.12|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|4.72|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|5.41|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|5.6|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|5.93|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|7.58|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|7.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thoc6|THOC6]]|0.575|
|[[:human genes:t:tp53|TP53]]|0.572|
|[[:human genes:m:med23|MED23]]|0.557|
|[[:human genes:w:wdr24|WDR24]]|0.556|
|[[:human genes:z:znf592|ZNF592]]|0.552|
|[[:human genes:s:sp3|SP3]]|0.543|
|[[:human genes:t:trim33|TRIM33]]|0.538|
|[[:human genes:d:dcaf5|DCAF5]]|0.524|
|[[:human genes:b:btaf1|BTAF1]]|0.524|
|[[:human genes:a:actb|ACTB]]|0.524|
|[[:human genes:s:spop|SPOP]]|0.515|
|[[:human genes:s:serf2|SERF2]]|0.513|
|[[:human genes:b:bap1|BAP1]]|0.512|
|[[:human genes:m:med13l|MED13L]]|0.506|
|[[:human genes:u:ube3a|UBE3A]]|0.504|
|[[:human genes:m:mllt1|MLLT1]]|0.503|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.499|
|[[:human genes:t:trim28|TRIM28]]|0.499|
|[[:human genes:m:mlst8|MLST8]]|0.496|
|[[:human genes:r:rptor|RPTOR]]|0.491|
|[[:human genes:i:id3|ID3]]|0.484|
|[[:human genes:c:casp3|CASP3]]|0.483|
|[[:human genes:b:bak1|BAK1]]|0.478|
|[[:human genes:u:ube2g1|UBE2G1]]|0.471|
|[[:human genes:a:arl14ep|ARL14EP]]|0.471|
|[[:human genes:t:tceb3|TCEB3]]|0.471|
|[[:human genes:n:nsd1|NSD1]]|0.465|
|[[:human genes:d:dohh|DOHH]]|0.461|
|[[:human genes:w:wdr59|WDR59]]|0.457|
|[[:human genes:m:mtor|MTOR]]|0.453|
|[[:human genes:l:lamtor2|LAMTOR2]]|0.451|
|[[:human genes:t:trip12|TRIP12]]|0.449|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.448|
|[[:human genes:c:casp9|CASP9]]|0.448|
|[[:human genes:m:meaf6|MEAF6]]|0.447|
|[[:human genes:m:max|MAX]]|0.446|
|[[:human genes:v:vdac2|VDAC2]]|0.446|
|[[:human genes:d:dr1|DR1]]|0.441|
|[[:human genes:m:mios|MIOS]]|0.437|
|[[:human genes:m:med13|MED13]]|0.437|
|[[:human genes:c:ccdc101|CCDC101]]|0.435|
|[[:human genes:f:fnip1|FNIP1]]|0.434|
|[[:human genes:a:asxl2|ASXL2]]|0.434|
|[[:human genes:t:tbc1d5|TBC1D5]]|0.433|
|[[:human genes:g:gabpa|GABPA]]|0.43|
|[[:human genes:o:otud5|OTUD5]]|0.427|
|[[:human genes:g:gfpt1|GFPT1]]|0.427|
|[[:human genes:h:hhex|HHEX]]|0.424|
|[[:human genes:c:cul3|CUL3]]|0.424|
|[[:human genes:p:pax5|PAX5]]|0.422|
|[[:human genes:e:eny2|ENY2]]|0.421|
|[[:human genes:k:khdrbs1|KHDRBS1]]|0.419|
|[[:human genes:i:id4|ID4]]|0.419|
|[[:human genes:c:csnk2b|CSNK2B]]|0.417|
|[[:human genes:c:cul4a|CUL4A]]|0.415|
|[[:human genes:t:triap1|TRIAP1]]|0.415|
|[[:human genes:d:dpagt1|DPAGT1]]|0.413|
|[[:human genes:s:ss18|SS18]]|0.413|
|[[:human genes:a:atf7ip|ATF7IP]]|0.412|
|[[:human genes:p:pmm2|PMM2]]|0.411|
|[[:human genes:m:march5|MARCH5]]|0.407|
|[[:human genes:s:sirt7|SIRT7]]|0.407|
|[[:human genes:t:thg1l|THG1L]]|0.406|
|[[:human genes:t:taf5l|TAF5L]]|0.405|
|[[:human genes:f:flcn|FLCN]]|0.404|
|[[:human genes:d:diablo|DIABLO]]|0.401|
|[[:human genes:m:med25|MED25]]|0.401|
|[[:human genes:a:apaf1|APAF1]]|0.401|
|[[:human genes:c:cbfb|CBFB]]|0.4|
|[[:human genes:s:srprb|SRPRB]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2967
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FBXO11 Expression in NALM6 Cells: 5.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>