FBXO7 [The Human Chemical-Genetic Interaction Map Project]

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======= FBXO7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FBXO7
  * **<color #00a2e8>Official Name</color>**: F-box protein 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25793|25793]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3I1|Q9Y3I1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FBXO7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FBXO7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605648|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. {ECO:0000269|PubMed:15145941, ECO:0000269|PubMed:16510124, ECO:0000269|PubMed:23933751}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|F-box-like|
|PI31 Prot N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|classical Lewy body|
|Lewy neurite|
|Lewy body corona|
|glial cytoplasmic inclusion|
|Lewy body core|
|positive regulation of autophagy of mitochondrion|
|negative regulation of oxidative stress-induced neuron death|
|regulation of oxidative stress-induced neuron death|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of cyclin-dependent protein kinase activity|
|mitochondrion disassembly|
|autophagy of mitochondrion|
|regulation of autophagy of mitochondrion|
|negative regulation of cellular response to oxidative stress|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of response to oxidative stress|
|negative regulation of lymphocyte differentiation|
|protein targeting to mitochondrion|
|regulation of oxidative stress-induced cell death|
|organelle disassembly|
|SCF ubiquitin ligase complex|
|establishment of protein localization to mitochondrion|
|regulation of cellular response to oxidative stress|
|protein localization to mitochondrion|
|ubiquitin binding|
|regulation of response to oxidative stress|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of leukocyte differentiation|
|negative regulation of G1/S transition of mitotic cell cycle|
|regulation of cyclin-dependent protein kinase activity|
|ubiquitin ligase complex|
|negative regulation of cell cycle G1/S phase transition|
|positive regulation of mitochondrion organization|
|positive regulation of autophagy|
|negative regulation of protein serine/threonine kinase activity|
|negative regulation of hemopoiesis|
|negative regulation of lymphocyte activation|
|regulation of G1/S transition of mitotic cell cycle|
|regulation of cell cycle G1/S phase transition|
|regulation of lymphocyte differentiation|
|negative regulation of leukocyte activation|
|regulation of mitochondrion organization|
|negative regulation of cell activation|
|negative regulation of neuron death|
|negative regulation of mitotic cell cycle phase transition|
|mitochondrial transport|
|negative regulation of protein kinase activity|
|negative regulation of cell cycle phase transition|
|negative regulation of kinase activity|
|ubiquitin-protein transferase activity|
|autophagy|
|process utilizing autophagic mechanism|
|regulation of leukocyte differentiation|
|negative regulation of transferase activity|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|protein polyubiquitination|
|negative regulation of mitotic cell cycle|
|regulation of neuron death|
|negative regulation of cell cycle process|
|regulation of autophagy|
|protein targeting|
|post-translational protein modification|
|positive regulation of cellular catabolic process|
|cellular component disassembly|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|establishment of protein localization to organelle|
|positive regulation of catabolic process|
|negative regulation of immune system process|
|mitochondrion organization|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|regulation of hemopoiesis|
|protein kinase binding|
|protein heterodimerization activity|
|regulation of neuron projection development|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|protein-containing complex|
|regulation of leukocyte activation|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|regulation of cell activation|
|regulation of neuron differentiation|
|protein catabolic process|
|protein ubiquitination|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|protein localization to organelle|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|regulation of kinase activity|
|cellular macromolecule catabolic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of transferase activity|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|regulation of catabolic process|
|intracellular protein transport|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|mitochondrion|
|proteolysis|
|regulation of organelle organization|
|regulation of protein phosphorylation|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|neurogenesis|
|regulation of immune system process|
|regulation of cell death|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp453|B02 10μM R08 exp453]]|-2.46|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.36|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-2.1|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-2.04|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-2.01|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2679
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FBXO7 Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>