FDPS [The Human Chemical-Genetic Interaction Map Project]

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======= FDPS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FDPS
  * **<color #00a2e8>Official Name</color>**: farnesyl diphosphate synthase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2224|2224]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14324|P14324]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FDPS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FDPS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/134629|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|polyprenyl synt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dimethylallyltranstransferase activity|
|geranyl diphosphate biosynthetic process|
|geranyl diphosphate metabolic process|
|geranyltranstransferase activity|
|farnesyl diphosphate biosynthetic process|
|farnesyl diphosphate metabolic process|
|terpenoid biosynthetic process|
|isoprenoid biosynthetic process|
|cholesterol biosynthetic process|
|regulation of sterol biosynthetic process|
|secondary alcohol biosynthetic process|
|regulation of cholesterol biosynthetic process|
|sterol biosynthetic process|
|regulation of cholesterol metabolic process|
|regulation of alcohol biosynthetic process|
|regulation of steroid biosynthetic process|
|alcohol biosynthetic process|
|regulation of steroid metabolic process|
|cholesterol metabolic process|
|terpenoid metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|isoprenoid metabolic process|
|organic hydroxy compound biosynthetic process|
|regulation of lipid biosynthetic process|
|phospholipid biosynthetic process|
|steroid metabolic process|
|alcohol metabolic process|
|phospholipid metabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|organic hydroxy compound metabolic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-4.14|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-3.78|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-3.59|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.92|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-2.88|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.85|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.79|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.74|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.73|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-2.64|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-2.58|
|[[:results:exp302|35°C R06 exp302]]|-2.56|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.51|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.5|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.46|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.21|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-2.2|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.13|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.07|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.06|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.06|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-2.06|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.03|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-2.01|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.94|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.93|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.93|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.92|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.91|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.9|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.85|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.83|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.83|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.82|
|[[:results:exp136|MS094 2μM R03 exp136]]|-1.78|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.77|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.73|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.72|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.7|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.75|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.79|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.81|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.85|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.85|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.9|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|2.02|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.1|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.14|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.21|
|[[:results:exp148|SB202190 10μM R03 exp148]]|2.29|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.43|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.51|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.53|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|2.68|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.9|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|3.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 141/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|11/28|
|bone|1/26|
|breast|6/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|4/21|
|liver|2/20|
|lung|21/75|
|lymphocyte|4/16|
|ovary|5/26|
|pancreas|3/24|
|peripheral nervous system|2/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|9/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 796
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FDPS Expression in NALM6 Cells: 7.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>