FER [The Human Chemical-Genetic Interaction Map Project]

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======= FER =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FER
  * **<color #00a2e8>Official Name</color>**: FER tyrosine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2241|2241]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16591|P16591]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FER&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FER|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176942|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Apr 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. {ECO:0000269|PubMed:12972546, ECO:0000269|PubMed:14517306, ECO:0000269|PubMed:19147545, ECO:0000269|PubMed:19339212, ECO:0000269|PubMed:19738202, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21518868, ECO:0000269|PubMed:22223638, ECO:0000269|PubMed:7623846, ECO:0000269|PubMed:9722593}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|SH2|
|Pkinase|
|FCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Kit signaling pathway|
|response to stem cell factor|
|cellular response to stem cell factor stimulus|
|insulin receptor signaling pathway via phosphatidylinositol 3-kinase|
|extracellular matrix-cell signaling|
|diapedesis|
|response to macrophage colony-stimulating factor|
|cellular response to macrophage colony-stimulating factor stimulus|
|negative regulation of mast cell activation involved in immune response|
|tyrosine phosphorylation of STAT protein|
|negative regulation of mast cell activation|
|interleukin-6-mediated signaling pathway|
|protein phosphatase 1 binding|
|response to platelet-derived growth factor|
|cell-cell adhesion mediated by cadherin|
|regulation of lamellipodium assembly|
|regulation of fibroblast migration|
|cellular response to interleukin-6|
|platelet-derived growth factor receptor signaling pathway|
|epidermal growth factor receptor binding|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|response to interleukin-6|
|receptor signaling pathway via JAK-STAT|
|receptor signaling pathway via STAT|
|cellular extravasation|
|regulation of lamellipodium organization|
|regulation of mast cell activation|
|non-membrane spanning protein tyrosine kinase activity|
|regulation of leukocyte degranulation|
|substrate adhesion-dependent cell spreading|
|regulation of myeloid leukocyte mediated immunity|
|extrinsic component of cytoplasmic side of plasma membrane|
|actin cytoskeleton reorganization|
|regulation of epidermal growth factor receptor signaling pathway|
|protein tyrosine kinase activity|
|insulin receptor signaling pathway|
|regulation of ERBB signaling pathway|
|positive regulation of actin filament polymerization|
|negative regulation of immune effector process|
|positive regulation of protein polymerization|
|cellular response to reactive oxygen species|
|cell cortex|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|negative regulation of immune response|
|microtubule cytoskeleton|
|positive regulation of NF-kappaB transcription factor activity|
|lipid binding|
|cellular response to insulin stimulus|
|regulation of regulated secretory pathway|
|regulation of actin filament polymerization|
|Fc-epsilon receptor signaling pathway|
|negative regulation of leukocyte activation|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|cell-substrate adhesion|
|protein autophosphorylation|
|response to reactive oxygen species|
|negative regulation of cell activation|
|positive regulation of supramolecular fiber organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of leukocyte mediated immunity|
|actin cytoskeleton|
|positive regulation of immune effector process|
|positive regulation of cytoskeleton organization|
|regulation of exocytosis|
|regulation of protein polymerization|
|response to insulin|
|nuclear chromatin|
|cellular response to oxidative stress|
|Fc receptor signaling pathway|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|positive regulation of DNA-binding transcription factor activity|
|cellular response to peptide hormone stimulus|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|cellular response to peptide|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of intracellular transport|
|regulation of cellular component size|
|leukocyte migration|
|response to oxidative stress|
|regulation of actin filament-based process|
|response to peptide hormone|
|regulation of DNA-binding transcription factor activity|
|negative regulation of immune system process|
|regulation of protein complex assembly|
|regulation of immune effector process|
|response to peptide|
|microtubule cytoskeleton organization|
|immune response-regulating cell surface receptor signaling pathway|
|actin cytoskeleton organization|
|positive regulation of cell migration|
|cell-cell adhesion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|cell junction|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|actin filament-based process|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|regulation of cell activation|
|cellular response to nitrogen compound|
|microtubule-based process|
|cytokine-mediated signaling pathway|
|mitotic cell cycle|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of secretion by cell|
|regulation of secretion|
|cellular component morphogenesis|
|regulation of cell migration|
|response to lipid|
|peptidyl-amino acid modification|
|response to hormone|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|cell migration|
|protein phosphorylation|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|response to cytokine|
|cytoskeleton organization|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|cell cycle|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cell development|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.74|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.77|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16244
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FER Expression in NALM6 Cells: 5.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>