FERMT1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= FERMT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FERMT1
  * **<color #00a2e8>Official Name</color>**: fermitin family member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55612|55612]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQL6|Q9BQL6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FERMT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FERMT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607900|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome. [provided by RefSeq, Dec 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. {ECO:0000269|PubMed:14634021, ECO:0000269|PubMed:17012746, ECO:0000269|PubMed:19804783}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FERM M|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of transforming growth factor-beta secretion|
|negative regulation of timing of anagen|
|negative regulation of hair follicle maturation|
|regulation of transforming growth factor-beta secretion|
|negative regulation of hair follicle development|
|negative regulation of hair cycle|
|regulation of timing of anagen|
|keratinocyte migration|
|regulation of hair follicle maturation|
|keratinocyte proliferation|
|negative regulation of protein import|
|negative regulation of protein import into nucleus|
|negative regulation of stem cell proliferation|
|negative regulation of epidermis development|
|negative regulation of nucleocytoplasmic transport|
|regulation of hair follicle development|
|positive regulation of cell adhesion mediated by integrin|
|basement membrane organization|
|regulation of hair cycle|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of protein localization to nucleus|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|establishment of epithelial cell polarity|
|negative regulation of intracellular protein transport|
|regulation of cell adhesion mediated by integrin|
|positive regulation of cell-matrix adhesion|
|regulation of protein import into nucleus|
|regulation of protein import|
|negative regulation of intracellular transport|
|regulation of stem cell proliferation|
|epithelial cell migration|
|regulation of epidermis development|
|epithelial cell proliferation|
|epithelium migration|
|tissue migration|
|integrin-mediated signaling pathway|
|ruffle membrane|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of nucleocytoplasmic transport|
|negative regulation of cellular protein localization|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cell-matrix adhesion|
|regulation of cellular response to transforming growth factor beta stimulus|
|regulation of protein localization to nucleus|
|establishment of cell polarity|
|positive regulation of cell-substrate adhesion|
|positive regulation of cytokine secretion|
|ameboidal-type cell migration|
|negative regulation of canonical Wnt signaling pathway|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|establishment or maintenance of cell polarity|
|actin filament binding|
|regulation of cytokine secretion|
|negative regulation of Wnt signaling pathway|
|regulation of cell-substrate adhesion|
|regulation of intracellular protein transport|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|positive regulation of protein secretion|
|regulation of cellular response to growth factor stimulus|
|regulation of canonical Wnt signaling pathway|
|positive regulation of peptide secretion|
|extracellular matrix organization|
|regulation of intracellular transport|
|regulation of Wnt signaling pathway|
|cytoskeleton|
|extracellular structure organization|
|positive regulation of cell adhesion|
|positive regulation of secretion by cell|
|focal adhesion|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of cellular protein localization|
|cell junction|
|cell population proliferation|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|cell migration|
|positive regulation of transport|
|regulation of protein localization|
|localization of cell|
|cell motility|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14475
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FERMT1 Expression in NALM6 Cells: -5.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>