FFAR2 [The Human Chemical-Genetic Interaction Map Project]

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======= FFAR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FFAR2
  * **<color #00a2e8>Official Name</color>**: free fatty acid receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2867|2867]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15552|O15552]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FFAR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FFAR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603823|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin- 8/IL-8 in response to the presence of microbes (PubMed:21037097). Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate (PubMed:12496283, PubMed:12711604). Exhibits a SCFA- independent constitutive G protein-coupled receptor activity (PubMed:23066016). {ECO:0000269|PubMed:12496283, ECO:0000269|PubMed:12684041, ECO:0000269|PubMed:12711604, ECO:0000269|PubMed:18801738, ECO:0000269|PubMed:21037097, ECO:0000269|PubMed:23066016, ECO:0000269|PubMed:23589301}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srv|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell surface pattern recognition receptor signaling pathway|
|positive regulation of acute inflammatory response to non-antigenic stimulus|
|regulation of acute inflammatory response to non-antigenic stimulus|
|leukocyte chemotaxis involved in inflammatory response|
|leukocyte migration involved in inflammatory response|
|positive regulation of interleukin-8 secretion|
|regulation of interleukin-8 secretion|
|lipid storage|
|mucosal immune response|
|positive regulation of acute inflammatory response|
|organ or tissue specific immune response|
|regulation of acute inflammatory response|
|positive regulation of interleukin-8 production|
|positive regulation of cytokine production involved in immune response|
|cellular response to fatty acid|
|positive regulation of chemokine production|
|regulation of interleukin-8 production|
|regulation of chemokine production|
|response to fatty acid|
|regulation of cytokine production involved in immune response|
|positive regulation of production of molecular mediator of immune response|
|cell projection|
|fat cell differentiation|
|innate immune response activating cell surface receptor signaling pathway|
|pattern recognition receptor signaling pathway|
|positive regulation of inflammatory response|
|positive regulation of cytokine secretion|
|regulation of production of molecular mediator of immune response|
|leukocyte chemotaxis|
|lipid binding|
|maintenance of location|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of cytokine secretion|
|cellular response to acid chemical|
|cell chemotaxis|
|regulation of peptide hormone secretion|
|positive regulation of immune effector process|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|lipid localization|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|response to acid chemical|
|positive regulation of response to biotic stimulus|
|leukocyte migration|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of multi-organism process|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|regulation of hormone levels|
|chemotaxis|
|taxis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|regulation of cytokine production|
|regulation of protein transport|
|G protein-coupled receptor activity|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of multi-organism process|
|regulation of secretion|
|response to lipid|
|positive regulation of immune response|
|cell migration|
|positive regulation of transport|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|chemical homeostasis|
|regulation of immune response|
|positive regulation of immune system process|
|locomotion|
|G protein-coupled receptor signaling pathway|
|defense response|
|integral component of plasma membrane|
|regulation of response to stress|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|homeostatic process|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7928
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FFAR2 Expression in NALM6 Cells: 1.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>