FGF8 [The Human Chemical-Genetic Interaction Map Project]

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======= FGF8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FGF8
  * **<color #00a2e8>Official Name</color>**: fibroblast growth factor 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2253|2253]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55075|P55075]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGF8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGF8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600483|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111). {ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:8663044}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell migration involved in mesendoderm migration|
|corticotropin hormone secreting cell differentiation|
|mesendoderm migration|
|thyroid-stimulating hormone-secreting cell differentiation|
|dorsal/ventral axon guidance|
|mesodermal cell migration|
|neural plate morphogenesis|
|forebrain dorsal/ventral pattern formation|
|neuroendocrine cell differentiation|
|otic vesicle formation|
|midbrain-hindbrain boundary development|
|otic vesicle morphogenesis|
|mesendoderm development|
|neural plate development|
|forebrain morphogenesis|
|rostrocaudal neural tube patterning|
|adenohypophysis development|
|epithelial to mesenchymal transition involved in endocardial cushion formation|
|regulation of odontogenesis of dentin-containing tooth|
|otic vesicle development|
|cell migration involved in gastrulation|
|organ induction|
|branching involved in salivary gland morphogenesis|
|signal transduction involved in regulation of gene expression|
|endocardial cushion formation|
|fibroblast growth factor receptor binding|
|thyroid gland development|
|male genitalia development|
|forebrain regionalization|
|subpallium development|
|pharyngeal system development|
|regulation of odontogenesis|
|developmental induction|
|motor neuron axon guidance|
|positive regulation of G protein-coupled receptor signaling pathway|
|embryonic hindlimb morphogenesis|
|outflow tract septum morphogenesis|
|aorta morphogenesis|
|branching involved in blood vessel morphogenesis|
|cardiac epithelial to mesenchymal transition|
|cell proliferation in forebrain|
|salivary gland morphogenesis|
|dopaminergic neuron differentiation|
|forebrain neuron development|
|salivary gland development|
|blood vessel remodeling|
|negative regulation of cardiac muscle tissue development|
|brain morphogenesis|
|neural tube patterning|
|endocardial cushion morphogenesis|
|regulation of animal organ formation|
|hindlimb morphogenesis|
|chemoattractant activity|
|glandular epithelial cell differentiation|
|pituitary gland development|
|lung morphogenesis|
|exocrine system development|
|endocardial cushion development|
|neuroepithelial cell differentiation|
|branching involved in ureteric bud morphogenesis|
|genitalia development|
|positive regulation of organ growth|
|negative regulation of striated muscle tissue development|
|positive chemotaxis|
|negative regulation of muscle organ development|
|mesenchyme morphogenesis|
|negative regulation of muscle tissue development|
|aorta development|
|forebrain neuron differentiation|
|positive regulation of mitotic nuclear division|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|heart looping|
|artery morphogenesis|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|forebrain generation of neurons|
|positive regulation of nuclear division|
|determination of heart left/right asymmetry|
|embryonic heart tube morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|epithelial to mesenchymal transition|
|outflow tract morphogenesis|
|endoderm development|
|cardiac septum morphogenesis|
|neural precursor cell proliferation|
|diencephalon development|
|embryonic heart tube development|
|nephron tubule development|
|regulation of cardiac muscle tissue development|
|renal tubule development|
|fibroblast growth factor receptor signaling pathway|
|central nervous system neuron development|
|positive regulation of animal organ morphogenesis|
|dorsal/ventral pattern formation|
|metanephros development|
|kidney morphogenesis|
|artery development|
|ureteric bud development|
|epithelium migration|
|mesonephric epithelium development|
|positive regulation of cell division|
|mesonephric tubule development|
|BMP signaling pathway|
|canonical Wnt signaling pathway|
|mesonephros development|
|tissue migration|
|regulation of organ growth|
|columnar/cuboidal epithelial cell differentiation|
|nephron epithelium development|
|inner ear morphogenesis|
|gland morphogenesis|
|tissue remodeling|
|response to BMP|
|cellular response to BMP stimulus|
|cellular response to fibroblast growth factor stimulus|
|cardiac septum development|
|response to fibroblast growth factor|
|ear morphogenesis|
|determination of left/right symmetry|
|odontogenesis|
|endocrine system development|
|determination of bilateral symmetry|
|nephron development|
|specification of symmetry|
|mesoderm development|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|cardiac chamber morphogenesis|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|epithelial tube formation|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|regulation of G protein-coupled receptor signaling pathway|
|morphogenesis of embryonic epithelium|
|negative regulation of neuron apoptotic process|
|tube formation|
|limb morphogenesis|
|appendage morphogenesis|
|positive regulation of mitotic cell cycle|
|male sex differentiation|
|mesenchymal cell differentiation|
|morphogenesis of a branching epithelium|
|gastrulation|
|neural tube development|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|regulation of cell division|
|morphogenesis of a branching structure|
|regulation of mitotic nuclear division|
|lung development|
|cardiac chamber development|
|positive regulation of developmental growth|
|ameboidal-type cell migration|
|respiratory tube development|
|pallium development|
|central nervous system neuron differentiation|
|limb development|
|appendage development|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of nuclear division|
|inner ear development|
|respiratory system development|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|gonad development|
|positive regulation of ERK1 and ERK2 cascade|
|development of primary sexual characteristics|
|anterior/posterior pattern specification|
|regulation of protein kinase B signaling|
|mesenchyme development|
|ear development|
|cell fate commitment|
|heart morphogenesis|
|regulation of peptidyl-tyrosine phosphorylation|
|sensory organ morphogenesis|
|telencephalon development|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|axon guidance|
|neuron projection guidance|
|sex differentiation|
|kidney development|
|renal system development|
|positive regulation of cell cycle process|
|embryonic organ morphogenesis|
|regulation of ERK1 and ERK2 cascade|
|epithelial tube morphogenesis|
|regulation of neuron death|
|angiogenesis|
|urogenital system development|
|regulation of developmental growth|
|regionalization|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|axonogenesis|
|MAPK cascade|
|positive regulation of cell cycle|
|response to oxidative stress|
|forebrain development|
|signal transduction by protein phosphorylation|
|external side of plasma membrane|
|blood vessel morphogenesis|
|axon development|
|gland development|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|skeletal system development|
|cellular response to growth factor stimulus|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|cardiovascular system development|
|heart development|
|response to growth factor|
|positive regulation of MAPK cascade|
|sensory organ development|
|chemotaxis|
|taxis|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|neuron projection development|
|developmental process involved in reproduction|
|regulation of growth|
|epithelial cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|brain development|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|head development|
|neuron development|
|cellular component morphogenesis|
|tube development|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-2.1|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.85|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.7|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16964
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGF8 Expression in NALM6 Cells: 0.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>