FGF9 [The Human Chemical-Genetic Interaction Map Project]

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======= FGF9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FGF9
  * **<color #00a2e8>Official Name</color>**: fibroblast growth factor 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2254|2254]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31371|P31371]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGF9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGF9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600921|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. {ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:8663044}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cell differentiation involved in phenotypic switching|
|negative regulation of phenotypic switching|
|negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching|
|regulation of cell differentiation involved in phenotypic switching|
|regulation of vascular smooth muscle cell differentiation involved in phenotypic switching|
|regulation of phenotypic switching|
|negative regulation of vascular smooth muscle cell differentiation|
|lung-associated mesenchyme development|
|positive regulation of activin receptor signaling pathway|
|regulation of timing of cell differentiation|
|regulation of development, heterochronic|
|regulation of vascular smooth muscle cell differentiation|
|male sex determination|
|positive regulation of vascular endothelial growth factor receptor signaling pathway|
|negative regulation of smooth muscle cell differentiation|
|positive regulation of vascular associated smooth muscle cell migration|
|fibroblast growth factor receptor binding|
|regulation of vascular associated smooth muscle cell migration|
|sex determination|
|regulation of activin receptor signaling pathway|
|positive regulation of cardiac muscle cell proliferation|
|positive regulation of mesenchymal cell proliferation|
|regulation of smooth muscle cell differentiation|
|positive regulation of smoothened signaling pathway|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|regulation of mesenchymal cell proliferation|
|positive regulation of cardiac muscle tissue growth|
|positive regulation of vascular smooth muscle cell proliferation|
|embryonic digestive tract development|
|positive regulation of heart growth|
|positive regulation of smooth muscle cell migration|
|regulation of cardiac muscle cell proliferation|
|substantia nigra development|
|positive regulation of cardiac muscle tissue development|
|positive regulation of organ growth|
|regulation of vascular smooth muscle cell proliferation|
|negative regulation of muscle cell differentiation|
|regulation of cardiac muscle tissue growth|
|regulation of smooth muscle cell migration|
|neural nucleus development|
|regulation of heart growth|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|regulation of smoothened signaling pathway|
|regulation of cardiac muscle tissue development|
|fibroblast growth factor receptor signaling pathway|
|chondrocyte differentiation|
|midbrain development|
|positive regulation of smooth muscle cell proliferation|
|positive regulation of cell division|
|basement membrane|
|regulation of organ growth|
|protein import into nucleus|
|inner ear morphogenesis|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular response to fibroblast growth factor stimulus|
|import into nucleus|
|negative regulation of vasculature development|
|response to fibroblast growth factor|
|ear morphogenesis|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|embryonic skeletal system development|
|osteoblast differentiation|
|digestive tract development|
|regulation of striated muscle tissue development|
|regulation of smooth muscle cell proliferation|
|male gonad development|
|development of primary male sexual characteristics|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|protein import|
|digestive system development|
|positive regulation of canonical Wnt signaling pathway|
|appendage morphogenesis|
|limb morphogenesis|
|regulation of muscle cell differentiation|
|male sex differentiation|
|protein localization to nucleus|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|regulation of cell division|
|lung development|
|heparin binding|
|positive regulation of developmental growth|
|cartilage development|
|respiratory tube development|
|positive regulation of Wnt signaling pathway|
|appendage development|
|limb development|
|positive regulation of epithelial cell proliferation|
|inner ear development|
|respiratory system development|
|gonad development|
|negative regulation of Wnt signaling pathway|
|development of primary sexual characteristics|
|regulation of protein kinase B signaling|
|ear development|
|mesenchyme development|
|connective tissue development|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|sensory organ morphogenesis|
|positive regulation of growth|
|ossification|
|nucleocytoplasmic transport|
|sex differentiation|
|nuclear transport|
|regulation of cellular response to growth factor stimulus|
|regulation of canonical Wnt signaling pathway|
|embryonic organ morphogenesis|
|angiogenesis|
|regulation of vasculature development|
|regulation of developmental growth|
|regulation of epithelial cell proliferation|
|eye development|
|regulation of Wnt signaling pathway|
|visual system development|
|sensory system development|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|blood vessel morphogenesis|
|reproductive structure development|
|reproductive system development|
|establishment of protein localization to organelle|
|embryonic organ development|
|blood vessel development|
|skeletal system development|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|sensory organ development|
|positive regulation of locomotion|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|protein localization to organelle|
|brain development|
|regulation of MAPK cascade|
|head development|
|tube development|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|protein phosphorylation|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|intracellular protein transport|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|phosphorylation|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|extracellular region|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13686
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGF9 Expression in NALM6 Cells: 2.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>