FGFR1OP [The Human Chemical-Genetic Interaction Map Project]

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======= FGFR1OP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEP43
  * **<color #00a2e8>Official Name</color>**: centrosomal protein 43
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11116|11116]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95684|O95684]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGFR1OP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGFR1OP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605392|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FOP dimer|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein tyrosine kinase inhibitor activity|
|microtubule anchoring|
|negative regulation of protein tyrosine kinase activity|
|negative regulation of peptidyl-tyrosine phosphorylation|
|regulation of protein tyrosine kinase activity|
|ciliary basal body-plasma membrane docking|
|cell projection|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|centriole|
|positive regulation of cell growth|
|organelle localization by membrane tethering|
|membrane docking|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of growth|
|mitotic cell cycle phase transition|
|negative regulation of transferase activity|
|cell cycle phase transition|
|cilium assembly|
|cilium organization|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|negative regulation of phosphorylation|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|protein kinase binding|
|microtubule cytoskeleton organization|
|centrosome|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|organelle localization|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|regulation of growth|
|microtubule-based process|
|mitotic cell cycle|
|perinuclear region of cytoplasm|
|regulation of cell cycle process|
|organelle assembly|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|protein homodimerization activity|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|regulation of cell cycle|
|cell cycle|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.77|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.87|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.11|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.578|
|[[:human genes:c:cep120|CEP120]]|0.483|
|[[:human genes:c:c16orf59|C16orf59]]|0.474|
|[[:human genes:e:eny2|ENY2]]|0.47|
|[[:human genes:t:tube1|TUBE1]]|0.469|
|[[:human genes:r:rptor|RPTOR]]|0.463|
|[[:human genes:d:dpagt1|DPAGT1]]|0.456|
|[[:human genes:c:c14orf80|C14orf80]]|0.451|
|[[:human genes:w:wdr24|WDR24]]|0.451|
|[[:human genes:d:dohh|DOHH]]|0.45|
|[[:human genes:b:bap1|BAP1]]|0.448|
|[[:human genes:t:tubd1|TUBD1]]|0.446|
|[[:human genes:c:cep44|CEP44]]|0.445|
|[[:human genes:s:srp9|SRP9]]|0.445|
|[[:human genes:t:thg1l|THG1L]]|0.443|
|[[:human genes:c:csnk2b|CSNK2B]]|0.441|
|[[:human genes:s:srp14|SRP14]]|0.434|
|[[:human genes:r:rnmt|RNMT]]|0.434|
|[[:human genes:c:casp2|CASP2]]|0.433|
|[[:human genes:u:ube2k|UBE2K]]|0.427|
|[[:human genes:c:c2cd3|C2CD3]]|0.414|
|[[:human genes:p:pmm2|PMM2]]|0.41|
|[[:human genes:m:mfn1|MFN1]]|0.404|
|[[:human genes:c:crls1|CRLS1]]|0.401|
|[[:human genes:a:actr10|ACTR10]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 196/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|9/28|
|bone|2/26|
|breast|11/33|
|central nervous system|5/56|
|cervix|2/4|
|colorectal|6/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|8/21|
|liver|6/20|
|lung|14/75|
|lymphocyte|0/16|
|ovary|12/26|
|pancreas|5/24|
|peripheral nervous system|5/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|9/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|10/22|
|urinary tract|10/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1734
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGFR1OP Expression in NALM6 Cells: 6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>