FIBP [The Human Chemical-Genetic Interaction Map Project]

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======= FIBP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FIBP
  * **<color #00a2e8>Official Name</color>**: FGF1 intracellular binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9158|9158]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43427|O43427]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FIBP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FIBP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608296|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity). {ECO:0000250|UniProtKB:Q6T938, ECO:0000269|PubMed:9806903}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FIBP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fibroblast growth factor binding|
|platelet aggregation|
|homotypic cell-cell adhesion|
|endomembrane system|
|fibroblast growth factor receptor signaling pathway|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|platelet activation|
|blood coagulation|
|coagulation|
|hemostasis|
|nuclear speck|
|wound healing|
|regulation of body fluid levels|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to growth factor|
|response to wounding|
|enzyme linked receptor protein signaling pathway|
|cell adhesion|
|biological adhesion|
|cell activation|
|cellular response to endogenous stimulus|
|mitochondrion|
|response to endogenous stimulus|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-2.27|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.18|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.12|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.1|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.09|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.96|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.86|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.83|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.83|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.83|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.82|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.81|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.75|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.75|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.74|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.7|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.71|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.77|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.8|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.83|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.88|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.93|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.96|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|2.04|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.06|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|2.57|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.78|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.79|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|4.09|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|5.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c2cd5|C2CD5]]|0.615|
|[[:human genes:k:kiaa0195|KIAA0195]]|0.585|
|[[:human genes:c:cdk5|CDK5]]|0.498|
|[[:human genes:a:arl15|ARL15]]|0.453|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16001
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FIBP Expression in NALM6 Cells: 5.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>