FIGF [The Human Chemical-Genetic Interaction Map Project]

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======= FIGF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VEGFD
  * **<color #00a2e8>Official Name</color>**: vascular endothelial growth factor D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2277|2277]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43915|O43915]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FIGF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FIGF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300091|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. {ECO:0000269|PubMed:21148085}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vascular endothelial growth factor receptor 3 binding|
|vascular endothelial growth factor receptor binding|
|positive regulation of mast cell chemotaxis|
|regulation of mast cell chemotaxis|
|induction of positive chemotaxis|
|platelet-derived growth factor receptor binding|
|vascular endothelial growth factor signaling pathway|
|positive regulation of positive chemotaxis|
|regulation of positive chemotaxis|
|dopaminergic neuron differentiation|
|chemoattractant activity|
|cellular response to vascular endothelial growth factor stimulus|
|positive chemotaxis|
|sprouting angiogenesis|
|platelet alpha granule lumen|
|vascular endothelial growth factor receptor signaling pathway|
|positive regulation of cell division|
|positive regulation of leukocyte chemotaxis|
|positive regulation of endothelial cell proliferation|
|regulation of leukocyte chemotaxis|
|regulation of endothelial cell proliferation|
|platelet degranulation|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|growth factor activity|
|positive regulation of angiogenesis|
|regulation of cell division|
|positive regulation of vasculature development|
|positive regulation of epithelial cell proliferation|
|regulation of leukocyte migration|
|regulation of chemotaxis|
|regulation of angiogenesis|
|angiogenesis|
|regulation of vasculature development|
|regulation of epithelial cell proliferation|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|blood vessel morphogenesis|
|blood vessel development|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cardiovascular system development|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell population proliferation|
|positive regulation of response to external stimulus|
|tube morphogenesis|
|response to bacterium|
|regulated exocytosis|
|enzyme linked receptor protein signaling pathway|
|exocytosis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|export from cell|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.09|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.92|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.75|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.74|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.98|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.03|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10972
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FIGF Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>