FIGN [The Human Chemical-Genetic Interaction Map Project]

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======= FIGN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FIGN
  * **<color #00a2e8>Official Name</color>**: fidgetin, microtubule severing factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55137|55137]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5HY92|Q5HY92]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FIGN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FIGN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605295|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. {ECO:0000269|PubMed:22672901}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AAA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microtubule-severing ATPase activity|
|microtubule severing|
|regulation of double-strand break repair via homologous recombination|
|cytoplasmic microtubule organization|
|regulation of double-strand break repair|
|regulation of DNA recombination|
|nuclear matrix|
|regulation of DNA repair|
|microtubule organizing center|
|protein C-terminus binding|
|regulation of response to DNA damage stimulus|
|ATPase activity|
|microtubule|
|regulation of DNA metabolic process|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|cell division|
|microtubule-based process|
|regulation of cellular response to stress|
|cytoskeleton organization|
|cell cycle|
|regulation of response to stress|
|ATP binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.23|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6429
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FIGN Expression in NALM6 Cells: -0.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>