FKBP14 [The Human Chemical-Genetic Interaction Map Project]

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======= FKBP14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FKBP14
  * **<color #00a2e8>Official Name</color>**: FKBP prolyl isomerase 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55033|55033]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NWM8|Q9NWM8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FKBP14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FKBP14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614505|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the FK506-binding protein family of peptidyl-prolyl cis-trans isomerases. The encoded protein is found in the lumen of the endoplasmic reticulum, where it is thought to accelerate protein folding. Defects in this gene are a cause of a type of Ehlers-Danlos syndrome (EDS). Both a protein-coding variant and noncoding variants are transcribed from this gene. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  PPIases accelerate the folding of proteins during protein synthesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FKBP C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein peptidyl-prolyl isomerization|
|peptidyl-prolyl cis-trans isomerase activity|
|IRE1-mediated unfolded protein response|
|peptidyl-proline modification|
|endoplasmic reticulum unfolded protein response|
|cellular response to unfolded protein|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|response to topologically incorrect protein|
|response to endoplasmic reticulum stress|
|endoplasmic reticulum lumen|
|calcium ion binding|
|peptidyl-amino acid modification|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-2.17|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-2.1|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.73|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.87|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.9|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.91|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18680
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FKBP14 Expression in NALM6 Cells: 4.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>