FKBP8 [The Human Chemical-Genetic Interaction Map Project]

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======= FKBP8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FKBP8
  * **<color #00a2e8>Official Name</color>**: FKBP prolyl isomerase 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23770|23770]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14318|Q14318]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FKBP8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FKBP8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604840|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TPR 1|
|FKBP C|
|TPR 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dorsal/ventral neural tube patterning|
|positive regulation of BMP signaling pathway|
|disordered domain specific binding|
|neural tube patterning|
|peptidyl-prolyl cis-trans isomerase activity|
|protein peptidyl-prolyl isomerization|
|peptidyl-proline modification|
|smoothened signaling pathway|
|dorsal/ventral pattern formation|
|multicellular organism growth|
|cell fate specification|
|regulation of BMP signaling pathway|
|mitochondrial membrane|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|integral component of endoplasmic reticulum membrane|
|neural tube development|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cell fate commitment|
|regulation of cellular response to growth factor stimulus|
|camera-type eye development|
|regionalization|
|eye development|
|visual system development|
|sensory system development|
|developmental growth|
|growth|
|negative regulation of protein phosphorylation|
|pattern specification process|
|negative regulation of phosphorylation|
|sensory organ development|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|protein-containing complex|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|tube development|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|embryo development|
|negative regulation of cell death|
|endoplasmic reticulum|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|identical protein binding|
|cell death|
|negative regulation of protein metabolic process|
|epithelium development|
|mitochondrion|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-3.28|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-3.17|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.98|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.57|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.425|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4124
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FKBP8 Expression in NALM6 Cells: 6.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>