FKBPL [The Human Chemical-Genetic Interaction Map Project]

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======= FKBPL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FKBPL
  * **<color #00a2e8>Official Name</color>**: FKBP prolyl isomerase like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=63943|63943]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UIM3|Q9UIM3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FKBPL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FKBPL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617076|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21. {ECO:0000269|PubMed:15664193}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TPR 2|
|TPR 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of blood vessel branching|
|regulation of morphogenesis of a branching structure|
|protein stabilization|
|regulation of morphogenesis of an epithelium|
|regulation of protein stability|
|regulation of angiogenesis|
|regulation of vasculature development|
|response to radiation|
|regulation of anatomical structure morphogenesis|
|response to abiotic stimulus|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.55|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.1|
|[[:results:exp303|39°C R06 exp303]]|-1.8|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.75|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.7|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.73|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.81|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.84|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.89|
|[[:results:exp302|35°C R06 exp302]]|1.9|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.91|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.92|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.92|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.93|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.37|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.51|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.7|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|3.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:ankrd49|ANKRD49]]|0.556|
|[[:human genes:p:ppcdc|PPCDC]]|0.483|
|[[:human genes:p:pmvk|PMVK]]|0.456|
|[[:human genes:r:rpia|RPIA]]|0.449|
|[[:human genes:z:zcrb1|ZCRB1]]|0.447|
|[[:human genes:d:dnlz|DNLZ]]|0.425|
|[[:human genes:d:dazap1|DAZAP1]]|0.416|
|[[:human genes:t:tubd1|TUBD1]]|0.416|
|[[:human genes:g:got2|GOT2]]|0.414|
|[[:human genes:c:c15orf41|C15orf41]]|0.412|
|[[:human genes:b:brap|BRAP]]|0.408|
|[[:human genes:c:cxorf56|CXorf56]]|0.404|
|[[:human genes:p:pgm3|PGM3]]|0.403|
|[[:human genes:f:fam98b|FAM98B]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 976
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FKBPL Expression in NALM6 Cells: 2.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>