FMN2 [The Human Chemical-Genetic Interaction Map Project]

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======= FMN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FMN2
  * **<color #00a2e8>Official Name</color>**: formin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56776|56776]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZ56|Q9NZ56]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FMN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FMN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606373|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. This protein mediates the formation of an actin mesh that positions the spindle during oogenesis and also regulates the formation of actin filaments in the nucleus. This protein also forms a perinuclear actin/focal-adhesion system that regulates the shape and position of the nucleus during cell migration. Mutations in this gene have been associated with infertility and also with an autosomal recessive form of intellectual disability (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress- induced cell cycle arrest. Protects cells against apoptosis by protecting CDKN1A against degradation. {ECO:0000250, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FH2|
|Drf FH1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|homologous chromosome movement towards spindle pole involved in homologous chromosome segregation|
|formin-nucleated actin cable assembly|
|meiotic chromosome movement towards spindle pole|
|formin-nucleated actin cable organization|
|polar body extrusion after meiotic divisions|
|establishment of meiotic spindle localization|
|parallel actin filament bundle assembly|
|chromosome movement towards spindle pole|
|meiotic cytokinesis|
|positive regulation of actin nucleation|
|regulation of actin nucleation|
|positive regulation of double-strand break repair|
|female meiotic nuclear division|
|establishment of spindle localization|
|spindle localization|
|homologous chromosome segregation|
|microvillus|
|actin filament bundle assembly|
|positive regulation of DNA repair|
|actin filament bundle organization|
|establishment of chromosome localization|
|chromosome localization|
|regulation of double-strand break repair|
|oogenesis|
|meiotic chromosome segregation|
|positive regulation of actin filament polymerization|
|cytoskeleton-dependent cytokinesis|
|positive regulation of response to DNA damage stimulus|
|cytokinesis|
|meiosis I|
|meiosis I cell cycle process|
|spindle|
|regulation of DNA repair|
|positive regulation of protein polymerization|
|female gamete generation|
|negative regulation of protein catabolic process|
|cell cortex|
|cytoplasmic vesicle membrane|
|meiotic nuclear division|
|regulation of actin filament polymerization|
|meiotic cell cycle process|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|cellular response to hypoxia|
|positive regulation of DNA metabolic process|
|positive regulation of supramolecular fiber organization|
|cellular response to decreased oxygen levels|
|cellular response to oxygen levels|
|actin cytoskeleton|
|regulation of response to DNA damage stimulus|
|nuclear chromosome segregation|
|positive regulation of cytoskeleton organization|
|meiotic cell cycle|
|regulation of protein polymerization|
|actin filament organization|
|positive regulation of protein complex assembly|
|germ cell development|
|regulation of actin filament organization|
|actin binding|
|microtubule-based movement|
|chromosome segregation|
|nuclear division|
|negative regulation of catabolic process|
|organelle fission|
|response to hypoxia|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|cellular process involved in reproduction in multicellular organism|
|regulation of DNA metabolic process|
|response to decreased oxygen levels|
|establishment of organelle localization|
|regulation of cellular component size|
|response to oxygen levels|
|regulation of protein catabolic process|
|regulation of actin filament-based process|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|cell division|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|actin filament-based process|
|organelle localization|
|positive regulation of organelle organization|
|developmental process involved in reproduction|
|microtubule-based process|
|gamete generation|
|perinuclear region of cytoplasm|
|regulation of cellular response to stress|
|molecular function|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|nucleolus|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|endoplasmic reticulum membrane|
|regulation of cellular component biogenesis|
|regulation of catabolic process|
|multi-organism reproductive process|
|negative regulation of cell death|
|cell cycle process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|amide transport|
|establishment of protein localization|
|cell development|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3774
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FMN2 Expression in NALM6 Cells: -0.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>