FOXB1 [The Human Chemical-Genetic Interaction Map Project]

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======= FOXB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXB1
  * **<color #00a2e8>Official Name</color>**: forkhead box B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27023|27023]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99853|Q99853]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619961|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fork head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell migration in diencephalon|
|mammillothalamic axonal tract development|
|mammillary body development|
|inferior colliculus development|
|corpora quadrigemina development|
|mammillary axonal complex development|
|axon target recognition|
|epithelial cell differentiation involved in mammary gland alveolus development|
|hypothalamus cell migration|
|floor plate development|
|thalamus development|
|mammary gland epithelial cell differentiation|
|mammary gland alveolus development|
|mammary gland lobule development|
|hypothalamus development|
|lactation|
|visual learning|
|visual behavior|
|telencephalon cell migration|
|mammary gland epithelium development|
|forebrain cell migration|
|somitogenesis|
|body fluid secretion|
|diencephalon development|
|associative learning|
|somite development|
|midbrain development|
|segmentation|
|spinal cord development|
|limbic system development|
|mammary gland development|
|negative regulation of neuron apoptotic process|
|learning|
|neural tube development|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|anterior/posterior pattern specification|
|telencephalon development|
|learning or memory|
|cognition|
|response to light stimulus|
|regulation of neuron death|
|urogenital system development|
|regionalization|
|axonogenesis|
|forebrain development|
|axon development|
|gland development|
|sequence-specific DNA binding|
|cell morphogenesis involved in neuron differentiation|
|pattern specification process|
|response to radiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of body fluid levels|
|cell part morphogenesis|
|cell morphogenesis involved in differentiation|
|behavior|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|neuron projection development|
|epithelial cell differentiation|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|cellular component morphogenesis|
|tube development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|cell migration|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|neuron differentiation|
|cell motility|
|localization of cell|
|epithelium development|
|secretion|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|response to abiotic stimulus|
|locomotion|
|nervous system process|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|neurogenesis|
|cell development|
|regulation of cell death|
|tissue development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.98|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.81|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.83|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.9|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2471
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXB1 Expression in NALM6 Cells: -2.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>