FOXK2 [The Human Chemical-Genetic Interaction Map Project]

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======= FOXK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXK2
  * **<color #00a2e8>Official Name</color>**: forkhead box K2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3607|3607]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01167|Q01167]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147685|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta- catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). {ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:25805136}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fork head|
|FHA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter|
|regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter|
|NADH regeneration|
|glucose catabolic process to pyruvate|
|canonical glycolysis|
|glycolytic process through glucose-6-phosphate|
|glycolytic process through fructose-6-phosphate|
|glucose catabolic process|
|NADH metabolic process|
|glycolytic process|
|ATP generation from ADP|
|regulation of gluconeogenesis|
|NAD metabolic process|
|ADP metabolic process|
|hexose catabolic process|
|nucleoside diphosphate phosphorylation|
|purine ribonucleoside diphosphate metabolic process|
|nucleotide phosphorylation|
|purine nucleoside diphosphate metabolic process|
|monosaccharide catabolic process|
|ribonucleoside diphosphate metabolic process|
|pyruvate metabolic process|
|transcription regulatory region sequence-specific DNA binding|
|nucleoside diphosphate metabolic process|
|negative regulation of autophagy|
|cellular glucose homeostasis|
|regulation of carbohydrate biosynthetic process|
|glucose metabolic process|
|regulation of glucose metabolic process|
|carbohydrate catabolic process|
|regulation of cellular carbohydrate metabolic process|
|hexose metabolic process|
|glucose homeostasis|
|carbohydrate homeostasis|
|response to starvation|
|monosaccharide metabolic process|
|ATP metabolic process|
|regulation of carbohydrate metabolic process|
|magnesium ion binding|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|negative regulation of cellular catabolic process|
|protein deubiquitination|
|protein modification by small protein removal|
|negative regulation of catabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|regulation of autophagy|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|sequence-specific DNA binding|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|small molecule catabolic process|
|nucleotide metabolic process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|nucleoside phosphate metabolic process|
|carbohydrate metabolic process|
|response to nutrient levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|nucleobase-containing small molecule metabolic process|
|DNA-binding transcription factor activity|
|cellular chemical homeostasis|
|regulation of cellular catabolic process|
|negative regulation of transcription by RNA polymerase II|
|organophosphate metabolic process|
|cellular homeostasis|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|chemical homeostasis|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|phosphorylation|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.19|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.07|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.01|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.97|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.96|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.95|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.94|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4247
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXK2 Expression in NALM6 Cells: 6.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>