FOXL2 [The Human Chemical-Genetic Interaction Map Project]

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======= FOXL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXL2
  * **<color #00a2e8>Official Name</color>**: forkhead box L2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=668|668]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P58012|P58012]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605597|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans- differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fork head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cysteine-type endopeptidase regulator activity involved in apoptotic process|
|female somatic sex determination|
|female sex determination|
|somatic sex determination|
|granulosa cell differentiation|
|oocyte growth|
|positive regulation of luteinizing hormone secretion|
|extraocular skeletal muscle development|
|regulation of follicle-stimulating hormone secretion|
|positive regulation of follicle-stimulating hormone secretion|
|regulation of luteinizing hormone secretion|
|positive regulation of gonadotropin secretion|
|regulation of gonadotropin secretion|
|apoptotic DNA fragmentation|
|uterus development|
|sex determination|
|DNA catabolic process, endonucleolytic|
|apoptotic nuclear changes|
|cellular component disassembly involved in execution phase of apoptosis|
|DNA catabolic process|
|ubiquitin conjugating enzyme binding|
|embryonic eye morphogenesis|
|oocyte development|
|estrogen receptor binding|
|oocyte differentiation|
|regulation of endocrine process|
|ovarian follicle development|
|execution phase of apoptosis|
|intercellular bridge|
|oogenesis|
|developmental cell growth|
|female gonad development|
|cell growth|
|development of primary female sexual characteristics|
|female sex differentiation|
|skeletal muscle tissue development|
|positive regulation of hormone secretion|
|female gamete generation|
|skeletal muscle organ development|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|single fertilization|
|eye morphogenesis|
|positive regulation of cysteine-type endopeptidase activity|
|fertilization|
|positive regulation of endopeptidase activity|
|positive regulation of peptidase activity|
|gonad development|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|development of primary sexual characteristics|
|regulation of cysteine-type endopeptidase activity|
|sensory organ morphogenesis|
|germ cell development|
|sex differentiation|
|regulation of hormone secretion|
|striated muscle tissue development|
|embryonic organ morphogenesis|
|muscle organ development|
|muscle tissue development|
|nucleic acid phosphodiester bond hydrolysis|
|camera-type eye development|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of proteolysis|
|eye development|
|visual system development|
|sensory system development|
|nucleobase-containing compound catabolic process|
|developmental growth|
|growth|
|cellular component disassembly|
|positive regulation of secretion by cell|
|regulation of endopeptidase activity|
|reproductive structure development|
|reproductive system development|
|heterocycle catabolic process|
|embryonic organ development|
|cellular nitrogen compound catabolic process|
|positive regulation of secretion|
|aromatic compound catabolic process|
|regulation of peptidase activity|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|muscle structure development|
|organic cyclic compound catabolic process|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|regulation of hormone levels|
|sensory organ development|
|embryonic morphogenesis|
|regulation of system process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|gamete generation|
|positive regulation of cell death|
|regulation of proteolysis|
|DNA metabolic process|
|regulation of secretion by cell|
|positive regulation of hydrolase activity|
|regulation of secretion|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|negative regulation of transcription by RNA polymerase II|
|cellular macromolecule catabolic process|
|apoptotic process|
|animal organ morphogenesis|
|embryo development|
|positive regulation of transport|
|multi-organism reproductive process|
|macromolecule catabolic process|
|programmed cell death|
|cell death|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.07|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.97|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18053
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXL2 Expression in NALM6 Cells: -2.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>